AIMS: Aim of this case-control study is the assessment of the relationship between antihypertensive treatment and incidence of diabetes in an unselected cohort of subjects participating in a screening program for diabetes. METHODS: A case-control study nested within a cohort of nondiabetic subjects with a mean follow-up of 27.7 ± 11.3 months was performed, comparing 40 cases of incident diabetes and 160 controls matched for age, sex, body mass index, fasting plasma glucose, 2-h post-load glycemia, smoking and alcohol abuse. RESULTS: When considering antihypertensive treatment at enrolment, a lower proportion of cases was exposed to ACE-inhibitors/angiotensin receptor blockers (ACE-i/ARB) in comparison with controls. A non-significant trend toward a higher exposure to diuretics, which were mainly represented by thiazide diuretics, was observed in cases. In a multivariate analysis, including both ACE-i/ARB and diuretics, a protective effect of ACEi/ARB, and an increased risk with diuretics were observed. Similar results were obtained in alternative models, after adjusting for systolic and diastolic blood pressure at enrolment, diagnosis of hypertension, concurrent treatment with β-blockers or calcium-channel blockers, and number of antihypertensive medications. CONCLUSIONS: Diuretics seem to be associated with a higher incidence of diabetes, whereas treatment with ACEi/ARB could have a protective effect.
AIMS: Aim of this case-control study is the assessment of the relationship between antihypertensive treatment and incidence of diabetes in an unselected cohort of subjects participating in a screening program for diabetes. METHODS: A case-control study nested within a cohort of nondiabetic subjects with a mean follow-up of 27.7 ± 11.3 months was performed, comparing 40 cases of incident diabetes and 160 controls matched for age, sex, body mass index, fasting plasma glucose, 2-h post-load glycemia, smoking and alcohol abuse. RESULTS: When considering antihypertensive treatment at enrolment, a lower proportion of cases was exposed to ACE-inhibitors/angiotensin receptor blockers (ACE-i/ARB) in comparison with controls. A non-significant trend toward a higher exposure to diuretics, which were mainly represented by thiazide diuretics, was observed in cases. In a multivariate analysis, including both ACE-i/ARB and diuretics, a protective effect of ACEi/ARB, and an increased risk with diuretics were observed. Similar results were obtained in alternative models, after adjusting for systolic and diastolic blood pressure at enrolment, diagnosis of hypertension, concurrent treatment with β-blockers or calcium-channel blockers, and number of antihypertensive medications. CONCLUSIONS: Diuretics seem to be associated with a higher incidence of diabetes, whereas treatment with ACEi/ARB could have a protective effect.
Authors: Michael H Olsen; Eigil Fossum; Aud Høieggen; Kristian Wachtell; Elsa Hjerkinn; Shawna D Nesbitt; Ulrik B Andersen; Robert A Phillips; Cynthia L Gaboury; Hans Ibsen; Sverre E Kjeldsen; Stevo Julius Journal: J Hypertens Date: 2005-04 Impact factor: 4.844
Authors: L Ramsay; B Williams; G Johnston; G MacGregor; L Poston; J Potter; N Poulter; G Russell Journal: J Hum Hypertens Date: 1999-09 Impact factor: 3.012
Authors: Lars H Lindholm; Mats Persson; Petar Alaupovic; Bo Carlberg; Anders Svensson; Ola Samuelsson Journal: J Hypertens Date: 2003-08 Impact factor: 4.844
Authors: Nadia A Khan; Brenda Hemmelgarn; Robert J Herman; Simon W Rabkin; Finlay A McAlister; Chaim M Bell; Rhian M Touyz; Raj Padwal; Lawrence A Leiter; Jeff L Mahon; Michael D Hill; Pierre Larochelle; Ross D Feldman; Ernesto L Schiffrin; Norman R C Campbell; Malcolm O Arnold; Gordon Moe; Tavis S Campbell; Alain Milot; James A Stone; Charlotte Jones; Richard I Ogilvie; Pavel Hamet; George Fodor; George Carruthers; Kevin D Burns; Marcel Ruzicka; Jacques dechamplain; George Pylypchuk; Robert Petrella; Jean-Martin Boulanger; Luc Trudeau; Robert A Hegele; Vincent Woo; Phil McFarlane; Michel Vallée; Jonathan Howlett; Peter Katzmarzyk; Sheldon Tobe; Richard Z Lewanczuk Journal: Can J Cardiol Date: 2008-06 Impact factor: 5.223
Authors: E Mannucci; A Ognibene; I Sposato; M Brogi; G Gallori; G Bardini; F Cremasco; G Messeri; C M Rotella Journal: Acta Diabetol Date: 2003-12 Impact factor: 4.280