Literature DB >> 2161380

Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina.

N Tuteja1, M Danciger, I Klisak, R Tuteja, G Inana, T Mohandas, R S Sparkes, D B Farber.   

Abstract

Cyclic GMP-phosphodiesterase (cGMP-PDE) plays a key role in the normal functioning of retinal rod photoreceptor cells. The enzyme is composed of alpha- and beta-catalytic subunits which are inhibited by two identical gamma-subunits. A cDNA encoding the gamma-subunits (PDE gamma) from human retina has been cloned and sequenced. The 1012-bp cDNA has a coding region of 261 bp which is highly homologous to those of the PDE gamma cDNAs from bovine and mouse retinas. Comparison of the deduced amino acid sequences of the proteins from the three species indicates that PDE gamma has been very well conserved through evolution. The mRNA encoded by the cloned cDNA is 1.0 kb long, is similar in size to the corresponding mRNAs from mouse, dog and bovine retinas and is not detected in ground squirrel retina. The PDEG gene has been assigned to human chromosome 17, probably in the region q21.1.

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Year:  1990        PMID： 2161380     DOI： 10.1016/0378-1119(90)90035-p

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  10 in total

Review 1.  Mouse chromosome 11.

Authors:  A M Buchberg; M S Buckwalter; S A Camper
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1990-10-25       Impact factor: 16.971

3.  DNA helicase IV from HeLa cells.

Authors:  N Tuteja; K Rahman; R Tuteja; A Falaschi
Journal:  Nucleic Acids Res       Date:  1991-07-11       Impact factor: 16.971

4.  A DNA helicase from human cells.

Authors:  N Tuteja; R Tuteja; K Rahman; L Y Kang; A Falaschi
Journal:  Nucleic Acids Res       Date:  1990-12-11       Impact factor: 16.971

5.  A nonsense mutation in PDE6H causes autosomal-recessive incomplete achromatopsia.

Authors:  Susanne Kohl; Frauke Coppieters; Françoise Meire; Simone Schaich; Susanne Roosing; Christina Brennenstuhl; Sylvia Bolz; Maria M van Genderen; Frans C C Riemslag; Robert Lukowski; Anneke I den Hollander; Frans P M Cremers; Elfride De Baere; Carel B Hoyng; Bernd Wissinger
Journal:  Am J Hum Genet       Date:  2012-08-16       Impact factor: 11.025

6.  Purification and properties of human DNA helicase VI.

Authors:  N Tuteja; A Ochem; P Taneja; R Tuteja; D Skopác; A Falaschi
Journal:  Nucleic Acids Res       Date:  1995-07-11       Impact factor: 16.971

7.  DNA helicase III from HeLa cells: an enzyme that acts preferentially on partially unwound DNA duplexes.

Authors:  N Tuteja; K Rahman; R Tuteja; A Ochem; D Skopac; A Falaschi
Journal:  Nucleic Acids Res       Date:  1992-10-25       Impact factor: 16.971

8.  Human DNA helicase V, a novel DNA unwinding enzyme from HeLa cells.

Authors:  N Tuteja; K Rahman; R Tuteja; A Falaschi
Journal:  Nucleic Acids Res       Date:  1993-05-25       Impact factor: 16.971

9.  Map refinement of locus RP13 to human chromosome 17p13.3 in a second family with autosomal dominant retinitis pigmentosa.

Authors:  T L Kojis; C Heinzmann; P Flodman; J T Ngo; R S Sparkes; M A Spence; J B Bateman; J R Heckenlively
Journal:  Am J Hum Genet       Date:  1996-02       Impact factor: 11.025

10.  Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.

Authors:  N Tuteja; R Tuteja; A Ochem; P Taneja; N W Huang; A Simoncsits; S Susic; K Rahman; L Marusic; J Chen
Journal:  EMBO J       Date:  1994-10-17       Impact factor: 11.598
  10 in total

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