Literature DB >> 2161351

ACTH response induced by interleukin-1 is mediated by CRF secretion stimulated by hypothalamic PGE.

T Watanabe1, A Morimoto, Y Sakata, N Murakami.   

Abstract

We investigated whether hypothalamic prostaglandin E2 (PGE2) and corticotropin releasing factor (CRF) are responsible for the development of the adrenocorticotropic hormone (ACTH) response induced by interleukin-1 alpha (IL-1 alpha). The present results show that ACTH responses induced by intravenous injection of IL-1 alpha were suppressed by systemic pretreatment with indomethacin and that intrahypothalamic injection of PGE2 stimulates the secretion of ACTH. Furthermore, systemic pretreatment with anti-CRF antibody significantly suppressed the ACTH response induced by intrahypothalamic injection of PGE2. These data suggest that the ACTH response induced by IL-1 is mediated by CRF secretion stimulated by hypothalamic PGE2.

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Year:  1990        PMID： 2161351     DOI： 10.1007/BF01954238

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  16 in total

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Journal:  Science       Date:  1987-10-23       Impact factor: 47.728

2.  Interleukin-1 stimulates ACTH release by an indirect action which requires endogenous corticotropin releasing factor.

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Journal:  Endocrinology       Date:  1987-10       Impact factor: 4.736

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Journal:  Science       Date:  1987-10-23       Impact factor: 47.728

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Journal:  J Appl Physiol       Date:  1974-03       Impact factor: 3.531

5.  Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones.

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Journal:  Science       Date:  1986-08-08       Impact factor: 47.728

6.  Activation of ACTH release is mediated by the same molecule as the final mediator, PGE2, of febrile response in rats.

Authors:  N Murakami; T Watanabe
Journal:  Brain Res       Date:  1989-01-23       Impact factor: 3.252

7.  Multiple control of fever production in the central nervous system of rabbits.

Authors:  A Morimoto; N Murakami; T Nakamori; T Watanabe
Journal:  J Physiol       Date:  1988-03       Impact factor: 5.182

8.  Evidence for separate mechanisms of induction of biphasic fever inside and outside the blood-brain barrier in rabbits.

Authors:  A Morimoto; N Murakami; T Nakamori; T Watanabe
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Review 9.  Interleukin-1.

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Authors:  J T Stitt
Journal:  J Physiol       Date:  1973-07       Impact factor: 5.182
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  15 in total

1.  Evidence for an intramedullary prostaglandin-dependent mechanism in the activation of stress-related neuroendocrine circuitry by intravenous interleukin-1.

Authors:  A Ericsson; C Arias; P E Sawchenko
Journal:  J Neurosci       Date:  1997-09-15       Impact factor: 6.167

2.  ACTH release induced in rats by noradrenaline is mediated by prostaglandin E2.

Authors:  T Watanabe; A Morimoto; K Morimoto; T Nakamori; N Murakami
Journal:  J Physiol       Date:  1991-11       Impact factor: 5.182

3.  Prostaglandin E2 is involved in adrenocorticotrophic hormone release during swimming exercise in rats.

Authors:  T Watanabe; A Morimoto; Y Sakata; N C Long; N Murakami
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4.  Possible involvement of prostaglandins in psychological stress-induced responses in rats.

Authors:  A Morimoto; T Watanabe; K Morimoto; T Nakamori; N Murakami
Journal:  J Physiol       Date:  1991-11       Impact factor: 5.182

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Authors:  T Watanabe; A Morimoto; N Murakami
Journal:  Pflugers Arch       Date:  1991-12       Impact factor: 3.657

6.  Bicuculline enhances the corticosterone secretion induced by lipopolysaccharide and interleukin-1 alpha in male rats.

Authors:  A L Guo; F Petraglia; R E Nappi; M Criscuolo; G Ficarra; C Salvestroni; A D Genazzani; G P Trentini; A R Genazzani
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Journal:  J Physiol       Date:  1994-02-15       Impact factor: 5.182

8.  Activation of vagal afferents after intravenous injection of interleukin-1beta: role of endogenous prostaglandins.

Authors:  M Ek; M Kurosawa; T Lundeberg; A Ericsson
Journal:  J Neurosci       Date:  1998-11-15       Impact factor: 6.167

9.  Distinct brain vascular cell types manifest inducible cyclooxygenase expression as a function of the strength and nature of immune insults.

Authors:  Jennifer C Schiltz; Paul E Sawchenko
Journal:  J Neurosci       Date:  2002-07-01       Impact factor: 6.167

10.  Effect of naproxen on the hypothalamic-pituitary-adrenal axis in healthy volunteers.

Authors:  Agnes M M Eijsbouts; Marlies J E Kempers; Renske S A Kramer; Maria T E Hopman; Frank H J van den Hoogen; Ronald F J M Laan; Ad R M M Hermus; Fred C G J Sweep; Leo B A van de Putte
Journal:  Br J Clin Pharmacol       Date:  2009-01       Impact factor: 4.335
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