Literature DB >> 21611840

(31)P NMR correlation maps of (18)O/ (16)O chemical shift isotopic effects for phosphometabolite labeling studies.

Nenad Juranić1, Emirhan Nemutlu, Song Zhang, Petras Dzeja, Andre Terzic, Slobodan Macura.   

Abstract

Intramolecular correlations among the (18)O-labels of metabolic oligophosphates, mapped by J-decoupled (31)P NMR 2D chemical shift correlation spectroscopy, impart stringent constraints to the (18)O-isotope distributions over the whole oligophosphate moiety. The multiple deduced correlations of isotopic labels enable determination of site-specific fractional isotope enrichments and unravel the isotopologue statistics. This approach ensures accurate determination of (18)O-labeling rates of phosphometabolites, critical in biochemical energy conversion and metabolic flux transmission. The biological usefulness of the J-decoupled (31)P NMR 2D chemical shift correlation maps was validated on adenosine tri-phosphate fractionally (18)O labeled in perfused mammalian hearts.

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Year:  2011        PMID： 21611840      PMCID： PMC3230932          DOI： 10.1007/s10858-011-9515-3

Source DB:  PubMed          Journal:  J Biomol NMR        ISSN： 0925-2738            Impact factor:   2.835


  14 in total

1.  Adenylate kinase AK1 knockout heart: energetics and functional performance under ischemia-reperfusion.

Authors:  Darko Pucar; Peter Bast; Richard J Gumina; Lynette Lim; Carmen Drahl; Nenad Juranic; Slobodan Macura; Edwin Janssen; Be Wieringa; Andre Terzic; Petras P Dzeja
Journal:  Am J Physiol Heart Circ Physiol       Date:  2002-08       Impact factor: 4.733

2.  Mapping hypoxia-induced bioenergetic rearrangements and metabolic signaling by 18O-assisted 31P NMR and 1H NMR spectroscopy.

Authors:  Darko Pucar; Petras P Dzeja; Peter Bast; Richard J Gumina; Carmen Drahl; Lynette Lim; Nenad Juranic; Slobodan Macura; Andre Terzic
Journal:  Mol Cell Biochem       Date:  2004 Jan-Feb       Impact factor: 3.396

3.  Isotopic (18O) shift in 31P nuclear magnetic resonance applied to a study of enzyme-catalyzed phosphate--phosphate exchange and phosphate (oxygen)--water exchange reactions.

Authors:  M Cohn; A Hu
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

4.  Kinetic mechanism and rate-limiting steps of focal adhesion kinase-1.

Authors:  Jessica L Schneck; Jacques Briand; Stephanie Chen; Ruth Lehr; Patrick McDevitt; Baoguang Zhao; Angela Smallwood; Nestor Concha; Khyati Oza; Robert Kirkpatrick; Kang Yan; James P Villa; Thomas D Meek; Sara H Thrall
Journal:  Biochemistry       Date:  2010-08-24       Impact factor: 3.162

Review 5.  18O and 17O effects on 31P NMR as probes of enzymatic reactions of phosphate compounds.

Authors:  M Cohn
Journal:  Annu Rev Biophys Bioeng       Date:  1982

6.  Compromised energetics in the adenylate kinase AK1 gene knockout heart under metabolic stress.

Authors:  D Pucar; E Janssen; P P Dzeja; N Juranic; S Macura; B Wieringa; A Terzic
Journal:  J Biol Chem       Date:  2000-12-29       Impact factor: 5.157

7.  Cellular energetics in the preconditioned state: protective role for phosphotransfer reactions captured by 18O-assisted 31P NMR.

Authors:  D Pucar; P P Dzeja; P Bast; N Juranic; S Macura; A Terzic
Journal:  J Biol Chem       Date:  2001-10-02       Impact factor: 5.157

8.  Subunit interaction during catalysis: alternating site cooperativity in photophosphorylation shown by substrate modulation of [18O]ATP species formation.

Authors:  D D Hackney; G Rosen; P D Boyer
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

9.  Adenosine triphosphate utilization rates and metabolic pool sizes in intact cells measured by transfer of 18O from water.

Authors:  S M Dawis; T F Walseth; M A Deeg; R A Heyman; R M Graeff; N D Goldberg
Journal:  Biophys J       Date:  1989-01       Impact factor: 4.033

10.  The topology of metabolic isotope labeling networks.

Authors:  Michael Weitzel; Wolfgang Wiechert; Katharina Nöh
Journal:  BMC Bioinformatics       Date:  2007-08-29       Impact factor: 3.169
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  3 in total

1.  Electron spray ionization mass spectrometry and 2D 31P NMR for monitoring 18O/16O isotope exchange and turnover rates of metabolic oligophosphates.

Authors:  Emirhan Nemutlu; Nenad Juranic; Song Zhang; Lawrence E Ward; Tumpa Dutta; K Sreekumaran Nair; Andre Terzic; Slobodan Macura; Petras P Dzeja
Journal:  Anal Bioanal Chem       Date:  2012-03-18       Impact factor: 4.142

2.  Dynamic phosphometabolomic profiling of human tissues and transgenic models by 18O-assisted ³¹P NMR and mass spectrometry.

Authors:  Emirhan Nemutlu; Song Zhang; Anu Gupta; Nenad O Juranic; Slobodan I Macura; Andre Terzic; Arshad Jahangir; Petras Dzeja
Journal:  Physiol Genomics       Date:  2012-01-10       Impact factor: 3.107

Review 3.  18O-assisted dynamic metabolomics for individualized diagnostics and treatment of human diseases.

Authors:  Emirhan Nemutlu; Song Zhang; Nenad O Juranic; Andre Terzic; Slobodan Macura; Petras Dzeja
Journal:  Croat Med J       Date:  2012-12       Impact factor: 1.351
  3 in total

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