| Literature DB >> 21609758 |
Abstract
Red blood cell (RBC) transfusion is an essential practice in modern medicine, one that is entirely dependent on the availability of donor blood. Constraints in donor supply have led to proposals that transfusible RBC could be manufactured from stem cells. While it is possible to generate small amounts of RBC in vitro, very large numbers of cells are required to be of clinical significance. We explore the challenges facing large scale manufacture of RBC and technological developments required for such a scenario to be realised.Entities:
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Year: 2011 PMID： 21609758 DOI： 10.1016/j.biotechadv.2011.05.002
Source DB: PubMed Journal: Biotechnol Adv ISSN： 0734-9750 Impact factor: 14.227