OBJECTIVE: To assess the relationship between serum chemokine CXC ligand 5 (CXCL5) and intima-media thickness (IMT) of the common carotid artery, a marker of preclinical atherosclerosis. DESIGN, PATIENTS AND MEASUREMENTS: We measured the IMT (mean of three segments of both carotid arteries by ultrasonography), serum CXCL5, fasting plasma glucose, serum insulin, serum urea, serum uric acid, HbA1c, serum CRP, adiponectin and lipid profile of 730 Chinese type 2 diabetic participants older than 30 years in a cross-sectional community-based study performed in downtown Shanghai. RESULTS: Serum CXCL5 correlated with carotid IMT (r = 0·112, P = 0·019) after adjustment for age, gender, serum CRP and HbA1c. Multivariate linear regression analysis demonstrated that age (P = 2·30 × 10(-7) ), gender (P = 2·70 × 10(-2) ), systolic blood pressure (P = 9·26 × 10(-3) ), serum CRP (P = 2·12 × 10(-2) ), low-density lipoprotein cholesterol (P = 2·40 × 10(-2) ), CXCL5 (P = 5·27 × 10(-3) ) and high-density lipoprotein cholesterol (P = 3·80 × 10(-3) ) were independently associated with carotid IMT. CONCLUSIONS: Serum CXCL5 is an important determinant of carotid artery IMT in patients with type 2 diabetes. The correlation is independent of inflammation and glucose control.
OBJECTIVE: To assess the relationship between serum chemokine CXC ligand 5 (CXCL5) and intima-media thickness (IMT) of the common carotid artery, a marker of preclinical atherosclerosis. DESIGN, PATIENTS AND MEASUREMENTS: We measured the IMT (mean of three segments of both carotid arteries by ultrasonography), serum CXCL5, fasting plasma glucose, serum insulin, serum urea, serum uric acid, HbA1c, serum CRP, adiponectin and lipid profile of 730 Chinese type 2 diabeticparticipants older than 30 years in a cross-sectional community-based study performed in downtown Shanghai. RESULTS: Serum CXCL5 correlated with carotid IMT (r = 0·112, P = 0·019) after adjustment for age, gender, serum CRP and HbA1c. Multivariate linear regression analysis demonstrated that age (P = 2·30 × 10(-7) ), gender (P = 2·70 × 10(-2) ), systolic blood pressure (P = 9·26 × 10(-3) ), serum CRP (P = 2·12 × 10(-2) ), low-density lipoprotein cholesterol (P = 2·40 × 10(-2) ), CXCL5 (P = 5·27 × 10(-3) ) and high-density lipoprotein cholesterol (P = 3·80 × 10(-3) ) were independently associated with carotid IMT. CONCLUSIONS: Serum CXCL5 is an important determinant of carotid artery IMT in patients with type 2 diabetes. The correlation is independent of inflammation and glucose control.
Authors: Yonghong Feng; Anca Dorhoi; Hans-Joachim Mollenkopf; Hongyun Yin; Zhengwei Dong; Ling Mao; Jun Zhou; Aixiao Bi; Stephan Weber; Jeroen Maertzdorf; Gang Chen; Yang Chen; Stefan H E Kaufmann Journal: J Infect Dis Date: 2014-07-01 Impact factor: 5.226
Authors: Amber L Beitelshees; Christina L Aquilante; Hooman Allayee; Taimour Y Langaee; Gregory J Welder; Richard S Schofield; Issam Zineh Journal: Hum Genomics Date: 2012-08-02 Impact factor: 4.639
Authors: Shimona Madalli; Martina Beyrau; James Whiteford; Johan Duchene; Inderpal Singh Nandhra; Nimesh S A Patel; Madhur P Motwani; Derek W Gilroy; Christoph Thiemermann; Sussan Nourshargh; Ramona S Scotland Journal: Biol Sex Differ Date: 2015-11-26 Impact factor: 5.027
Authors: Saranya Ravi; Robert N Schuck; Eleanor Hilliard; Craig R Lee; Xuming Dai; Kaitlin Lenhart; Monte S Willis; Brian C Jensen; George A Stouffer; Cam Patterson; Jonathan C Schisler Journal: Am J Pathol Date: 2017-11-16 Impact factor: 4.307