BACKGROUND: The purpose of this study of human papillomavirus (HPV), Epstein-Barr virus (EBV), p21, and p53 in sinonasal inverted papilloma (IP) was to help elucidate its pathogenesis. METHODS: Seventy-three IPs, 48 nasal polyps, and 85 hypertrophied turbinates were subjected to HPV polymerase chain reaction (PCR) study. Seventy-three IPs, 30 nasal polyps, and 32 hypertrophied turbinates were subjected to EBV in situ hybridization (ISH), p21, and p53 immunohistochemical (IHC) studies. RESULTS: HPV was positive in 3 of 73 IPs (4.1%). All specimens were EBV negative. In all, 99% of IPs showed strong and diffuse p21 nuclear reactivity. Most nasal polyps and hypertrophied turbinates showed weak to moderate immunoreactivity of the basal and parabasal cells. Only focal p53 immunoreactivity of the basal and parabasal cells was found in 19% of IPs and 40% of nasal polyps. CONCLUSIONS: HPV prevalence of our IP is low. EBV is not present in IP. High p21 and low p53 expression in IP suggests a non-p53-dependent regulation pathway.
BACKGROUND: The purpose of this study of human papillomavirus (HPV), Epstein-Barr virus (EBV), p21, and p53 in sinonasal inverted papilloma (IP) was to help elucidate its pathogenesis. METHODS: Seventy-three IPs, 48 nasal polyps, and 85 hypertrophied turbinates were subjected to HPV polymerase chain reaction (PCR) study. Seventy-three IPs, 30 nasal polyps, and 32 hypertrophied turbinates were subjected to EBV in situ hybridization (ISH), p21, and p53 immunohistochemical (IHC) studies. RESULTS:HPV was positive in 3 of 73 IPs (4.1%). All specimens were EBV negative. In all, 99% of IPs showed strong and diffuse p21 nuclear reactivity. Most nasal polyps and hypertrophied turbinates showed weak to moderate immunoreactivity of the basal and parabasal cells. Only focal p53 immunoreactivity of the basal and parabasal cells was found in 19% of IPs and 40% of nasal polyps. CONCLUSIONS:HPV prevalence of our IP is low. EBV is not present in IP. High p21 and low p53 expression in IP suggests a non-p53-dependent regulation pathway.
Authors: Pieter J Slootweg; Alfio Ferlito; Antonio Cardesa; Lester D R Thompson; Jennifer L Hunt; Primož Strojan; Robert P Takes; Asterios Triantafyllou; Julia A Woolgar; Alessandra Rinaldo; Kenneth O Devaney; Leon Barnes Journal: Eur Arch Otorhinolaryngol Date: 2012-05-18 Impact factor: 2.503
Authors: Giant C Lin; Adam Scheel; Sarah Akkina; Steven Chinn; Martin Graham; Christine Komarck; Heather Walline; Jonathan B McHugh; Mark E Prince; Thomas E Carey; Mark A Zacharek Journal: Int Forum Allergy Rhinol Date: 2013-08-26 Impact factor: 3.858
Authors: Wesley H Stepp; Zainab Farzal; Adam J Kimple; Charles S Ebert; Brent A Senior; Adam M Zanation; Brian D Thorp Journal: Int Forum Allergy Rhinol Date: 2021-05-06 Impact factor: 5.426