BACKGROUND: Cancers of the upper aerodigestive tract (UADT; including oral cavity, pharynx, larynx and oesophagus) have high incidence rates all over the world, and they are especially frequent in some parts of Latin America. However, the data on the role of the major risk factors in these areas are still limited. METHODS: We have evaluated the role of alcohol and tobacco consumption, based on 2,252 upper aerodigestive squamous-cell carcinoma cases and 1,707 controls from seven centres in Brazil, Argentina, and Cuba. RESULTS: We show that alcohol drinkers have a risk of UADT cancers that is up to five times higher than that of never-drinkers. A very strong effect of aperitifs and spirits as compared to other alcohol types was observed, with the ORs reaching 12.76 (CI 5.37-30.32) for oesophagus. Tobacco smokers were up to six times more likely to develop aerodigestive cancers than never-smokers, with the ORs reaching 11.14 (7.72-16.08) among current smokers for hypopharynx and larynx cancer. There was a trend for a decrease in risk after quitting alcohol drinking or tobacco smoking for all sites. The interactive effect of alcohol and tobacco was more than multiplicative. In this study, 65% of all UADT cases were attributable to a combined effect of alcohol and tobacco use. CONCLUSIONS: In this largest study on UADT cancer in Latin America, we have shown for the first time that a prevailing majority of UADT cancer cases is due to a combined effect of alcohol and tobacco use and could be prevented by quitting the use of either of these two agents.
BACKGROUND:Cancers of the upper aerodigestive tract (UADT; including oral cavity, pharynx, larynx and oesophagus) have high incidence rates all over the world, and they are especially frequent in some parts of Latin America. However, the data on the role of the major risk factors in these areas are still limited. METHODS: We have evaluated the role of alcohol and tobacco consumption, based on 2,252 upper aerodigestive squamous-cell carcinoma cases and 1,707 controls from seven centres in Brazil, Argentina, and Cuba. RESULTS: We show that alcohol drinkers have a risk of UADT cancers that is up to five times higher than that of never-drinkers. A very strong effect of aperitifs and spirits as compared to other alcohol types was observed, with the ORs reaching 12.76 (CI 5.37-30.32) for oesophagus. Tobacco smokers were up to six times more likely to develop aerodigestive cancers than never-smokers, with the ORs reaching 11.14 (7.72-16.08) among current smokers for hypopharynx and larynx cancer. There was a trend for a decrease in risk after quitting alcohol drinking or tobacco smoking for all sites. The interactive effect of alcohol and tobacco was more than multiplicative. In this study, 65% of all UADT cases were attributable to a combined effect of alcohol and tobacco use. CONCLUSIONS: In this largest study on UADTcancer in Latin America, we have shown for the first time that a prevailing majority of UADTcancer cases is due to a combined effect of alcohol and tobacco use and could be prevented by quitting the use of either of these two agents.
Authors: Gioia Di Credico; Valeria Edefonti; Jerry Polesel; Francesco Pauli; Nicola Torelli; Diego Serraino; Eva Negri; Daniele Luce; Isabelle Stucker; Keitaro Matsuo; Paul Brennan; Marta Vilensky; Leticia Fernandez; Maria Paula Curado; Ana Menezes; Alexander W Daudt; Rosalina Koifman; Victor Wunsch-Filho; Ivana Holcatova; Wolfgang Ahrens; Pagona Lagiou; Lorenzo Simonato; Lorenzo Richiardi; Claire Healy; Kristina Kjaerheim; David I Conway; Tatiana V Macfarlane; Peter Thomson; Antonio Agudo; Ariana Znaor; Leonardo F Boaventura Rios; Tatiana N Toporcov; Silvia Franceschi; Rolando Herrero; Joshua Muscat; Andrew F Olshan; Jose P Zevallos; Carlo La Vecchia; Deborah M Winn; Erich M Sturgis; Guojun Li; Eleonora Fabianova; Jolanda Lissowska; Dana Mates; Peter Rudnai; Oxana Shangina; Beata Swiatkowska; Kirsten Moysich; Zuo-Feng Zhang; Hal Morgenstern; Fabio Levi; Elaine Smith; Philip Lazarus; Cristina Bosetti; Werner Garavello; Karl Kelsey; Michael McClean; Heribert Ramroth; Chu Chen; Stephen M Schwartz; Thomas L Vaughan; Tongzhang Zheng; Gwenn Menvielle; Stefania Boccia; Gabriella Cadoni; Richard B Hayes; Mark Purdue; Maura Gillison; Stimson Schantz; Guo-Pei Yu; Hermann Brenner; Gypsyamber D'Souza; Neil D Gross; Shu-Chun Chuang; Paolo Boffetta; Mia Hashibe; Yuan-Chin Amy Lee; Luigino Dal Maso Journal: Oral Oncol Date: 2019-05-17 Impact factor: 5.337
Authors: Travis P Baggett; Yuchiao Chang; Daniel E Singer; Bianca C Porneala; Jessie M Gaeta; James J O'Connell; Nancy A Rigotti Journal: Am J Public Health Date: 2014-12-18 Impact factor: 9.308
Authors: Tatiana Natasha Toporcov; Ariana Znaor; Zuo-Feng Zhang; Guo-Pei Yu; Deborah M Winn; Qingyi Wei; Marta Vilensky; Thomas Vaughan; Peter Thomson; Renato Talamini; Neonila Szeszenia-Dabrowska; Erich M Sturgis; Elaine Smith; Oxana Shangina; Stephen M Schwartz; Stimson Schantz; Peter Rudnai; Lorenzo Richiardi; Heribert Ramroth; Mark P Purdue; Andrew F Olshan; José Eluf-Neto; Joshua Muscat; Raquel Ajub Moyses; Hal Morgenstern; Ana Menezes; Michael McClean; Keitaro Matsuo; Dana Mates; Tatiana V Macfarlane; Jolanta Lissowska; Fabio Levi; Philip Lazarus; Carlo La Vecchia; Pagona Lagiou; Sergio Koifman; Kristina Kjaerheim; Karl Kelsey; Ivana Holcatova; Rolando Herrero; Claire Healy; Richard B Hayes; Silvia Franceschi; Leticia Fernandez; Eleonora Fabianova; Alexander W Daudt; Otávio Alberto Curioni; Luigino Dal Maso; Maria Paula Curado; David I Conway; Chu Chen; Xavier Castellsague; Cristina Canova; Gabriella Cadoni; Paul Brennan; Stefania Boccia; José Leopoldo Ferreira Antunes; Wolfgang Ahrens; Antonio Agudo; Paolo Boffetta; Mia Hashibe; Yuan-Chin Amy Lee; Victor Wünsch Filho Journal: Int J Epidemiol Date: 2015-01-22 Impact factor: 7.196
Authors: Sandra Perdomo; Devasena Anantharaman; Matthieu Foll; Behnoush Abedi-Ardekani; Geoffroy Durand; Luciana Albina Reis Rosa; Reetta Holmila; Florence Le Calvez-Kelm; Eloiza H Tajara; Victor Wünsch-Filho; José Eduardo Levi; Marta Vilensky; Jerry Polesel; Ivana Holcatova; Lorenzo Simonato; Cristina Canova; Pagona Lagiou; James D McKay; Paul Brennan Journal: PLoS One Date: 2018-01-29 Impact factor: 3.240