Literature DB >> 21607107

Targeting leukemia stem cells: The new goal of therapy in adult acute myeloid leukemia.

Xavier Thomas1.   

Abstract

The most popular view of hematopoietic cell lineage organization is that of complex reactive or adaptative systems. Leukemia contains a subpopulation of cells that display characteristics of stem cells. These cells maintain tumor growth. The properties of leukemia stem cells indicate that current conventional chemotherapy, directed against the bulk of the tumor, will not be effective. Leukemia stem cells are quiescent and do not respond to cell cycle-specific cytotoxic agents used to treat leukemia and thus contribute to treatment failure. New strategies are required that specifically target this malignant stem cell population.

Entities:  

Keywords:  Acute myeloid leukemia; Leukemia stem cells; Prognosis; Targeted therapy

Year:  2009        PMID： 21607107      PMCID： PMC3097908          DOI： 10.4252/wjsc.v1.i1.49

Source DB:  PubMed          Journal:  World J Stem Cells        ISSN： 1948-0210            Impact factor:   5.326


  50 in total

1.  The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells.

Authors:  C T Jordan; D Upchurch; S J Szilvassy; M L Guzman; D S Howard; A L Pettigrew; T Meyerrose; R Rossi; B Grimes; D A Rizzieri; S M Luger; G L Phillips
Journal:  Leukemia       Date:  2000-10       Impact factor: 11.528

Review 2.  Stem cell niche: structure and function.

Authors:  Linheng Li; Ting Xie
Journal:  Annu Rev Cell Dev Biol       Date:  2005       Impact factor: 13.827

3.  Effect of priming with granulocyte-macrophage colony-stimulating factor in younger adults with newly diagnosed acute myeloid leukemia: a trial by the Acute Leukemia French Association (ALFA) Group.

Authors:  X Thomas; E Raffoux; S de Botton; C Pautas; P Arnaud; T de Revel; O Reman; C Terré; B Corront; C Gardin; Q-H Le; B Quesnel; C Cordonnier; J-H Bourhis; M Elhamri; P Fenaux; C Preudhomme; M Michallet; S Castaigne; H Dombret
Journal:  Leukemia       Date:  2007-01-25       Impact factor: 11.528

Review 4.  The hematopoietic stem cell in its place.

Authors:  Gregor B Adams; David T Scadden
Journal:  Nat Immunol       Date:  2006-04       Impact factor: 25.606

Review 5.  Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.

Authors:  A M Martelli; M Nyåkern; G Tabellini; R Bortul; P L Tazzari; C Evangelisti; L Cocco
Journal:  Leukemia       Date:  2006-06       Impact factor: 11.528

6.  A diphtheria toxin-interleukin 3 fusion protein is cytotoxic to primitive acute myeloid leukemia progenitors but spares normal progenitors.

Authors:  Michaela Feuring-Buske; Arthur E Frankel; Richard L Alexander; Brigitte Gerhard; Donna E Hogge
Journal:  Cancer Res       Date:  2002-03-15       Impact factor: 12.701

7.  Acute myeloblastic leukemia considered as a clonal hemopathy.

Authors:  E A McCulloch; A F Howatson; R N Buick; M D Minden; C A Izaguirre
Journal:  Blood Cells       Date:  1979-06-15

8.  JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells.

Authors:  Emmanuelle Passegué; Erwin F Wagner; Irving L Weissman
Journal:  Cell       Date:  2004-10-29       Impact factor: 41.582

9.  Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.

Authors:  Julie Lessard; Guy Sauvageau
Journal:  Nature       Date:  2003-04-20       Impact factor: 49.962

10.  DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells.

Authors:  Kellie V Rosinski; Nobuharu Fujii; Jeffrey K Mito; Kevin K W Koo; Suzanne M Xuereb; Olga Sala-Torra; James S Gibbs; Jerald P Radich; Yoshiki Akatsuka; Benoît J Van den Eynde; Stanley R Riddell; Edus H Warren
Journal:  Blood       Date:  2008-02-25       Impact factor: 22.113
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  1 in total

1.  High frequency of CD34+CD38-/low immature leukemia cells is correlated with unfavorable prognosis in acute myeloid leukemia.

Authors:  Adriana Plesa; Charles Dumontet; Eve Mattei; Ines Tagoug; Sandrine Hayette; Pierre Sujobert; Isabelle Tigaud; Marie Pierre Pages; Youcef Chelghoum; Fiorenza Baracco; Helene Labussierre; Sophie Ducastelle; Etienne Paubelle; Franck Emmanuel Nicolini; Mohamed Elhamri; Lydia Campos; Claudiu Plesa; Stéphane Morisset; Gilles Salles; Yves Bertrand; Mauricette Michallet; Xavier Thomas
Journal:  World J Stem Cells       Date:  2017-12-26       Impact factor: 5.326
  1 in total

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