| Literature DB >> 21605639 |
Juan C Bertoglio1, Mario A Calvo, Juan L Hancke, Rafael A Burgos, Antonella Riva, Paolo Morazzoni, Cesare Ponzone, Chiara Magni, Marcello Duranti.
Abstract
A lupin seed γ-conglutin-enriched preparation was tested in a glucose overload trial with both murine models and adult healthy volunteers. The results with rats showed a dose-dependent significant decrease of blood glucose concentration, which confirmed previous findings obtained with the purified protein. Moreover, three test-product doses equivalent to 630, 315, and 157.5 mg γ-conglutin, orally administered 30 min before the carbohydrate supply, showed a relevant hypoglycemic effect in human trials. Insulin concentrations were not significantly affected. The general hematic parameters did not change at all. This is the first report on the glucose-lowering effect of lupin γ-conglutin in human subjects.Entities:
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Year: 2011 PMID： 21605639 DOI： 10.1016/j.fitote.2011.05.007
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882