Literature DB >> 2160561

Determinants of coronavirus MHV pathogenesis are localized to 3' portions of the genome as determined by ribonucleic acid-ribonucleic acid recombination.

E Lavi1, E M Murray, S Makino, S A Stohlman, M M Lai, S R Weiss.   

Abstract

Recombinant viruses derived from coronaviruses mouse hepatitis virus strains JHM and A59, were used to map biologic properties of the virus to viral genes. The 3' portion (about 25%) of the viral genome, including the genes coding for all of the structural proteins, controls biologic properties such as organ tropism of the virus, pattern of the virus-induced central nervous system pathology in mice, plaque morphology, and virus yield in tissue culture.

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Year:  1990        PMID： 2160561

Source DB:  PubMed          Journal:  Lab Invest        ISSN： 0023-6837            Impact factor:   5.662


  18 in total

1.  Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3' one-third of the genome.

Authors:  Sonia Navas-Martin; Maarten Brom; Ming-Ming Chua; Richard Watson; Zhaozhu Qiu; Susan R Weiss
Journal:  J Virol       Date:  2006-11-01       Impact factor: 5.103

2.  Both spike and background genes contribute to murine coronavirus neurovirulence.

Authors:  Kathryn T Iacono; Lubna Kazi; Susan R Weiss
Journal:  J Virol       Date:  2006-07       Impact factor: 5.103

3.  Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice.

Authors:  Nadine De Albuquerque; Ehtesham Baig; Xuezhong Ma; Jianhua Zhang; William He; Andrea Rowe; Marlena Habal; Mingfeng Liu; Itay Shalev; Gregory P Downey; Reginald Gorczynski; Jagdish Butany; Julian Leibowitz; Susan R Weiss; Ian D McGilvray; M James Phillips; Eleanor N Fish; Gary A Levy
Journal:  J Virol       Date:  2006-11       Impact factor: 5.103

4.  Pathogenesis of chimeric MHV4/MHV-A59 recombinant viruses: the murine coronavirus spike protein is a major determinant of neurovirulence.

Authors:  J J Phillips; M M Chua; E Lavi; S R Weiss
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

5.  Demyelination determinants map to the spike glycoprotein gene of coronavirus mouse hepatitis virus.

Authors:  J Das Sarma; L Fu; J C Tsai; S R Weiss; E Lavi
Journal:  J Virol       Date:  2000-10       Impact factor: 5.103

6.  Coronavirus neurovirulence correlates with the ability of the virus to induce proinflammatory cytokine signals from astrocytes and microglia.

Authors:  Yun Li; Li Fu; Donna M Gonzales; Ehud Lavi
Journal:  J Virol       Date:  2004-04       Impact factor: 5.103

7.  The N-terminal domain of the murine coronavirus spike glycoprotein determines the CEACAM1 receptor specificity of the virus strain.

Authors:  Jean C Tsai; Bruce D Zelus; Kathryn V Holmes; Susan R Weiss
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

8.  The spike protein of murine coronavirus mouse hepatitis virus strain A59 is not cleaved in primary glial cells and primary hepatocytes.

Authors:  S T Hingley; I Leparc-Goffart; S R Weiss
Journal:  J Virol       Date:  1998-02       Impact factor: 5.103

9.  Targeted recombination within the spike gene of murine coronavirus mouse hepatitis virus-A59: Q159 is a determinant of hepatotropism.

Authors:  I Leparc-Goffart; S T Hingley; M M Chua; J Phillips; E Lavi; S R Weiss
Journal:  J Virol       Date:  1998-12       Impact factor: 5.103

Review 10.  Analysis of the molecular basis of neuropathogenesis of RNA viruses in experimental animals: relevance for human disease?

Authors:  G J Atkins; I M Balluz; G M Glasgow; M J Mabruk; V A Natale; J M Smyth; B J Sheahan
Journal:  Neuropathol Appl Neurobiol       Date:  1994-04       Impact factor: 8.090
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