BACKGROUND: The aim of this study was to compare imaging modalities for staging the neck in a prospective cohort of patients evaluated by CT, ultrasound with fine-needle aspiration cytology (FNAC), and [(18)F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/CT with the histologic evaluation of the neck dissection as the standard of reference. METHODS: In all, 76 consecutive patients were prospectively enrolled. RESULTS: Ultrasound-guided FNAC showed the highest level of agreement with histology for exact N classification. Ultrasound-guided FNAC showed the smallest percentage of overstaged patients, 7%, versus 16% with PET/CT, 13% with CT, and 13% with ultrasound. The rate of understaged patients was comparable between the imaging modalities. With regard to the endpoint N0 versus N+ there were no statistically significant differences to be found. CONCLUSIONS: Ultrasound-guided FNAC seems to correlate best with histologic staging compared with PET/CT and CT. None of the modality is reliable enough to replace elective neck treatment in cN0 necks.
BACKGROUND: The aim of this study was to compare imaging modalities for staging the neck in a prospective cohort of patients evaluated by CT, ultrasound with fine-needle aspiration cytology (FNAC), and [(18)F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/CT with the histologic evaluation of the neck dissection as the standard of reference. METHODS: In all, 76 consecutive patients were prospectively enrolled. RESULTS: Ultrasound-guided FNAC showed the highest level of agreement with histology for exact N classification. Ultrasound-guided FNAC showed the smallest percentage of overstaged patients, 7%, versus 16% with PET/CT, 13% with CT, and 13% with ultrasound. The rate of understaged patients was comparable between the imaging modalities. With regard to the endpoint N0 versus N+ there were no statistically significant differences to be found. CONCLUSIONS: Ultrasound-guided FNAC seems to correlate best with histologic staging compared with PET/CT and CT. None of the modality is reliable enough to replace elective neck treatment in cN0 necks.
Authors: Karl Christoph Sproll; Sabina Leydag; Henrik Holtmann; Lara K Schorn; Joel Aissa; Patric Kröpil; Wolfgang Kaisers; Csaba Tóth; Jörg Handschel; Julian Lommen Journal: J Cancer Res Clin Oncol Date: 2021-02-01 Impact factor: 4.553
Authors: Val J Lowe; Fenghai Duan; Rathan M Subramaniam; JoRean D Sicks; Justin Romanoff; Twyla Bartel; Jian Q Michael Yu; Brian Nussenbaum; Jeremy Richmon; Charles D Arnold; David Cognetti; Brendan C Stack Journal: J Clin Oncol Date: 2019-02-15 Impact factor: 44.544
Authors: R Maquieira; S K Haerle; G F Huber; A Soltermann; S R Haile; S J Stoeckli; Martina A Broglie Journal: Eur Arch Otorhinolaryngol Date: 2015-06-10 Impact factor: 2.503
Authors: Rikke Norling; Birgitte Marie Due Buron; Marianne Hamilton Therkildsen; Birthe Merete Henriksen; Christian von Buchwald; Michael Bachmann Nielsen Journal: PLoS One Date: 2014-03-20 Impact factor: 3.240
Authors: Stephan K Haerle; Thomas F Hany; Nader Ahmad; Irene Burger; Gerhard F Huber; Daniel T Schmid Journal: Cancer Imaging Date: 2013-02-20 Impact factor: 3.909