Literature DB >> 21604142

Profile of French community-dwelling older adults supplemented with vitamin D: findings and lessons.

Bruno Fantino1, Olivier Beauchet, Séverine Savignat, Béatrice Bouvard, Erick Legrand, Cédric Annweiler.   

Abstract

INTRODUCTION: The vast majority of older French adults exhibit some degree of hypovitaminosis D. The objective of this cross-sectional study was to determine the rate and the reasons for vitamin D prescription among older French adult community dwellers.
METHODS: Vitamin D supplementation was systematically assessed among 1876 French community dwellers aged ≥ 65 years. Theoretical indications for vitamin D supplementation were collected, ie, the causes of hypovitaminosis D (older age, male gender, kidney failure, undernutrition, polymorbidity) or its clinical complications (vertebral or non-vertebral fractures, gait disturbances, history of falls, muscle weakness, and cognitive impairment).
RESULTS: In total, 13.8% of the subjects (n=258) had vitamin D supplementation. They were more often malnourished (P=0.002), exhibited polymorbidity (P<0.001) and muscle weakness (P<0.001), and had a history of vertebral fractures (P<0.001), non-vertebral fractures (P<0.001), and accidental falls (P<0.001). Vitamin D supplementation was explained by the number of complications of hypovitaminosis D (odds ratio [OR]=1.61, P<0.001) including vertebral fractures (adjusted OR=1.49, P=0.007), non-vertebral fractures (adjusted OR=1.74, P=0.026), accidental falls (adjusted OR=1.44, P=0.015), and muscle weakness (adjusted OR=3.96, P<0.001), but not by the number of causes of hypovitaminosis D (P=0.464).
CONCLUSION: Even if vitamin D supplementation is selected well for appropriate patients, the rate of supplementation remains insufficient in France, and probably comes too late, ie, at the stage of complications of hypovitaminosis D. These findings should encourage physicians to supplement vitamin D more often and sooner in their elderly patients.

Entities:  

Mesh:

Substances:

Year:  2011        PMID: 21604142     DOI: 10.1007/s12325-011-0030-4

Source DB:  PubMed          Journal:  Adv Ther        ISSN: 0741-238X            Impact factor:   3.845


  4 in total

Review 1.  Possibility of a new anti-alzheimer's disease pharmaceutical composition combining memantine and vitamin D.

Authors:  Cédric Annweiler; Olivier Beauchet
Journal:  Drugs Aging       Date:  2012-02-01       Impact factor: 3.923

Review 2.  Vitamin D safety and requirements.

Authors:  Francisco J A de Paula; Clifford J Rosen
Journal:  Arch Biochem Biophys       Date:  2011-12-09       Impact factor: 4.013

3.  Alzheimer's disease--input of vitamin D with mEmantine assay (AD-IDEA trial): study protocol for a randomized controlled trial.

Authors:  Cédric Annweiler; Bruno Fantino; Elsa Parot-Schinkel; Samuel Thiery; Jennifer Gautier; Olivier Beauchet
Journal:  Trials       Date:  2011-10-20       Impact factor: 2.279

4.  Higher dietary vitamin D intake is associated with better survival among older women: Results from the French EPIDOS cohort.

Authors:  Jennifer Gautier; Jérémie Riou; Anne-Marie Schott; Hubert Blain; Yves Rolland; Patrick Saulnier; Cédric Annweiler
Journal:  Front Nutr       Date:  2022-09-08
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.