Literature DB >> 21603130

The Role of Phospholipase A(2)-derived Mediators in Obesity.

Marcia J Abbott1, Tianyi Tang, Hei Sook Sul.   

Abstract

Obesity has become an epidemic and its prevalence is increasing exponentially. A great deal of focus has been given to understanding the molecular processes that regulate obesity. The characterization of phospholipase A(2)s, especially adipose-specific PLA(2), have lead to a proposed role of their downstream products in the progression of obesity and obesity related disorders. This review summarizes recent developments in the role of PLA(2) and their downstream effects in the development of metabolic disorders.

Entities:  

Year:  2010        PMID： 21603130      PMCID： PMC3097474          DOI： 10.1016/j.ddmec.2011.01.003

Source DB:  PubMed          Journal:  Drug Discov Today Dis Mech        ISSN： 1740-6765


  50 in total

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Journal:  Cardiovasc Drugs Ther       Date:  2008-10-18       Impact factor: 3.727

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Authors:  C S Elangbam
Journal:  Vet Pathol       Date:  2009-01       Impact factor: 2.221
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Authors:  Christina C Leslie
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2.  Amelioration of obesity-related characteristics by a probiotic formulation in a high-fat diet-induced obese rat model.

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3.  Peptide Fraction pOh2 Exerts Antiadipogenic Activity through Inhibition of C/EBP-α and PPAR-γ Expression in 3T3-L1 Adipocytes.

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Journal:  Biomed Res Int       Date:  2017-03-23       Impact factor: 3.411

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Authors:  Chun-Yang Wang; Shu Liu; Xiao-Nv Xie; Zhi-Ying Luo; Li Yang; Zhi-Rong Tan
Journal:  Diabetes Metab Syndr Obes       Date:  2018-08-22       Impact factor: 3.168

5.  Urine and serum metabolite profiling of rats fed a high-fat diet and the anti-obesity effects of caffeine consumption.

Authors:  Hyang Yeon Kim; Mee Youn Lee; Hye Min Park; Yoo Kyoung Park; Jong Cheol Shon; Kwang-Hyeon Liu; Choong Hwan Lee
Journal:  Molecules       Date:  2015-02-13       Impact factor: 4.411

6.  cPLA2 blockade attenuates S100A7-mediated breast tumorigenicity by inhibiting the immunosuppressive tumor microenvironment.

Authors:  Sanjay Mishra; Manish Charan; Rajni Kant Shukla; Pranay Agarwal; Swati Misri; Ajeet K Verma; Dinesh K Ahirwar; Jalal Siddiqui; Kirti Kaul; Neety Sahu; Kunj Vyas; Ayush Arpit Garg; Anum Khan; Wayne O Miles; Jonathan W Song; Nidhi Bhutani; Ramesh K Ganju
Journal:  J Exp Clin Cancer Res       Date:  2022-02-08

7.  Targeting ROS and cPLA2/COX2 Expressions Ameliorated Renal Damage in Obese Mice with Endotoxemia.

Authors:  Jia-Feng Chang; Jih-Chen Yeh; Chun-Ta Ho; Shih-Hao Liu; Chih-Yu Hsieh; Ting-Ming Wang; Shu-Wei Chang; I-Ta Lee; Kuo-Yang Huang; Jen-Yu Wang; Wei-Ning Lin
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8.  Relationship Between the Gastrointestinal Side Effects of an Anti-Hypertensive Medication and Changes in the Serum Lipid Metabolome.

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  8 in total

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