AIM: Omentin-1, a novel adipokine expressed in visceral adipose tissue, is negatively correlated with insulin resistance and obesity. Decreased omentin-1 expression has been found in many chronic inflammatory diseases. However, the role of omentin-1 in coronary artery disease (CAD) has not been elucidated. The aim of the present study was to determine whether serum concentration of omentin-1 was independently associated with CAD. METHODS: One hundred and fifty five patients with CAD were divided into two groups: acute coronary syndrome (ACS) and stable angina pectoris (SAP). A total of 52 healthy participants served as controls. Serum concentrations of omentin-1 and interleukin-6 (IL-6) were measured using ELISA. The association of omentin-1 with CAD and cardiovascular disease risk factors was evaluated. RESULTS: Serum omentin-1 levels were lower in patients with ACS or SAP compared with controls (ACS, 113.08±61.43 ng/mL; SAP, 155.41±66.89 ng/mL; control, 254.00±72.9 ng/mL; P<0.01). Patients with ACS also had lower serum concentrations of omentin-1 compared with patients with SAP (P<0.01). Serum concentration of omentin-1 was negatively correlated with body mass index (r=-0.17, P<0.05) and serum IL-6 concentration (r=-0.19, P<0.05). Furthermore, multiple logistic regression analysis showed that serum omentin-1 concentrations were independently correlated with CAD. CONCLUSION: The findings suggest that serum concentrations of omentin-1 are related to CAD.
AIM: Omentin-1, a novel adipokine expressed in visceral adipose tissue, is negatively correlated with insulin resistance and obesity. Decreased omentin-1 expression has been found in many chronic inflammatory diseases. However, the role of omentin-1 in coronary artery disease (CAD) has not been elucidated. The aim of the present study was to determine whether serum concentration of omentin-1 was independently associated with CAD. METHODS: One hundred and fifty five patients with CAD were divided into two groups: acute coronary syndrome (ACS) and stable angina pectoris (SAP). A total of 52 healthy participants served as controls. Serum concentrations of omentin-1 and interleukin-6 (IL-6) were measured using ELISA. The association of omentin-1 with CAD and cardiovascular disease risk factors was evaluated. RESULTS: Serum omentin-1 levels were lower in patients with ACS or SAP compared with controls (ACS, 113.08±61.43 ng/mL; SAP, 155.41±66.89 ng/mL; control, 254.00±72.9 ng/mL; P<0.01). Patients with ACS also had lower serum concentrations of omentin-1 compared with patients with SAP (P<0.01). Serum concentration of omentin-1 was negatively correlated with body mass index (r=-0.17, P<0.05) and serum IL-6 concentration (r=-0.19, P<0.05). Furthermore, multiple logistic regression analysis showed that serum omentin-1 concentrations were independently correlated with CAD. CONCLUSION: The findings suggest that serum concentrations of omentin-1 are related to CAD.
Authors: Aletta Elisabeth Schutte; Hugo Willem Huisman; Rudolph Schutte; Johannes Marthinus van Rooyen; Leoné Malan; Catharina Maria Theresia Fourie; Nicolaas Theodore Malan Journal: Regul Pept Date: 2010-07-06
Authors: Celia M de Souza Batista; Rong-Ze Yang; Mi-Jeong Lee; Nicole M Glynn; Dao-Zhan Yu; Jessica Pray; Kelechi Ndubuizu; Susheel Patil; Alan Schwartz; Mark Kligman; Susan K Fried; Da-Wei Gong; Alan R Shuldiner; Toni I Pollin; John C McLenithan Journal: Diabetes Date: 2007-02-28 Impact factor: 9.461
Authors: Rong-Ze Yang; Mi-Jeong Lee; Hong Hu; Jessica Pray; Hai-Bin Wu; Barbara C Hansen; Alan R Shuldiner; Susan K Fried; John C McLenithan; Da-Wei Gong Journal: Am J Physiol Endocrinol Metab Date: 2006-03-10 Impact factor: 4.310
Authors: K Safranow; V Dziedziejko; R Rzeuski; E Czyzycka; A Wojtarowicz; A Bińczak-Kuleta; K Jakubowska; M Olszewska; A Ciechanowicz; Z Kornacewicz-Jach; B Machaliński; A Pawlik; D Chlubek Journal: Tissue Antigens Date: 2009-11
Authors: Sarah R Anthony; Adrienne R Guarnieri; Anamarie Gozdiff; Robert N Helsley; Albert Phillip Owens; Michael Tranter Journal: Clin Sci (Lond) Date: 2019-11-29 Impact factor: 6.124