Literature DB >> 21602586

Basic mechanisms of antiepileptic drugs and their pharmacokinetic/pharmacodynamic interactions: an update.

Władysław Lasoń1, Monika Dudra-Jastrzębska, Konrad Rejdak, Stanisław J Czuczwar.   

Abstract

This article aims to summarize the current views of AED action and the promising new targets for the pharmacotherapy of epilepsy. In the first section of this paper, a neurobiological basis of epilepsy treatment and brief pharmacological characteristics of classical and new AEDs will be presented. In the second part, the results of experimental studies that have combined AEDs with similar or different mechanisms of action will be discussed.

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Year:  2011        PMID： 21602586     DOI： 10.1016/s1734-1140(11)70497-2

Source DB:  PubMed          Journal:  Pharmacol Rep        ISSN： 1734-1140            Impact factor:   3.024


  16 in total

1.  Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in mice.

Authors:  James Johnson; Edward Alain B Pajarillo; Equar Taka; Romonia Reams; Deok-Soo Son; Michael Aschner; Eunsook Lee
Journal:  Neurotoxicology       Date:  2017-06-10       Impact factor: 4.294

Review 2.  New avenues for anti-epileptic drug discovery and development.

Authors:  Wolfgang Löscher; Henrik Klitgaard; Roy E Twyman; Dieter Schmidt
Journal:  Nat Rev Drug Discov       Date:  2013-09-20       Impact factor: 84.694

Review 3.  Nonconvulsive status epilepticus in adults - insights into the invisible.

Authors:  Raoul Sutter; Saskia Semmlack; Peter W Kaplan
Journal:  Nat Rev Neurol       Date:  2016-04-11       Impact factor: 42.937

4.  Influence of sildenafil on the anticonvulsant action of selected antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice.

Authors:  Dorota Nieoczym; Katarzyna Socała; Jarogniew J Łuszczki; Stanisław J Czuczwar; Piotr Wlaz
Journal:  J Neural Transm (Vienna)       Date:  2012-08       Impact factor: 3.575

Review 5.  The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis.

Authors:  Emilio Russo; Rita Citraro; Andrew Constanti; Giovambattista De Sarro
Journal:  Mol Neurobiol       Date:  2012-07-24       Impact factor: 5.682

Review 6.  Old versus New: Why Do We Need New Antiepileptic Drugs?

Authors:  Sang Kun Lee
Journal:  J Epilepsy Res       Date:  2014-12-31

7.  Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy.

Authors:  Anna Rapacz; Krzysztof Kamiński; Jolanta Obniska; Paulina Koczurkiewicz; Elżbieta Pękala; Barbara Filipek
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2017-02-10       Impact factor: 3.000

8.  Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene.

Authors:  Kinga Gawel; Waldemar A Turski; Wietske van der Ent; Benan J Mathai; Karolina J Kirstein-Smardzewska; Anne Simonsen; Camila V Esguerra
Journal:  Mol Neurobiol       Date:  2019-12-26       Impact factor: 5.590

9.  C-11, a New Antiepileptic Drug Candidate: Evaluation of the Physicochemical Properties and Impact on the Protective Action of Selected Antiepileptic Drugs in the Mouse Maximal Electroshock-Induced Seizure Model.

Authors:  Mirosław Zagaja; Aleksandra Szewczyk; Joanna Szala-Rycaj; Grzegorz Raszewski; Magdalena Chrościńska-Krawczyk; Michał Abram; Krzysztof Kamiński; Marta Andres-Mach
Journal:  Molecules       Date:  2021-05-24       Impact factor: 4.411

10.  Systematic review and meta-analysis of the efficacy and safety of perampanel in the treatment of partial-onset epilepsy.

Authors:  Warrington W Q Hsu; C W Sing; Ying He; Alan J Worsley; Ian C K Wong; Esther W Chan
Journal:  CNS Drugs       Date:  2013-10       Impact factor: 5.749
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