Literature DB >> 2160239

Rat liver contains a potent endogenous inhibitor of inositol 1,3,4,5-tetrakisphosphate 3-phosphatase.

M E Hodgson1, S B Shears.   

Abstract

When Ins(1,3,4,5)P4 was incubated with a rat liver 100,000 g supernatant, about 93% of the substrate was metabolized by a 5-phosphatase, and only 7% by a 3-phosphatase. Ion-exchange chromatography of the supernatant specifically increased its 3-phosphatase activity 72 +/- 3-fold. This activated enzyme was inhibited by a heat-stable factor present in both the soluble and particulate portions of the cell.

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Year:  1990        PMID： 2160239      PMCID： PMC1131373          DOI： 10.1042/bj2670831

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

1.  Purification and characterization of two types of soluble inositol phosphate 5-phosphomonoesterases from rat brain.

Authors:  C A Hansen; R A Johanson; M T Williamson; J R Williamson
Journal:  J Biol Chem       Date:  1987-12-25       Impact factor: 5.157

2.  Preferential localization of rat liver D-myo-inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase in bile-canalicular plasma membrane and 'late' endosomal vesicles.

Authors:  S B Shears; W H Evans; C J Kirk; R H Michell
Journal:  Biochem J       Date:  1988-12-01       Impact factor: 3.857

Review 3.  Metabolism of the inositol phosphates produced upon receptor activation.

Authors:  S B Shears
Journal:  Biochem J       Date:  1989-06-01       Impact factor: 3.857

4.  Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate.

Authors:  P J Cullen; R F Irvine; B K Drøbak; A P Dawson
Journal:  Biochem J       Date:  1989-05-01       Impact factor: 3.857

5.  The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase.

Authors:  S B Shears
Journal:  J Biol Chem       Date:  1989-11-25       Impact factor: 5.157

6.  Kinetic consequences of the inhibition by ATP of the metabolism of inositol (1,4,5) trisphosphate and inositol (1,3,4,5) tetrakisphosphate in liver. Different effects upon the 3- and 5-phosphatases.

Authors:  S B Shears
Journal:  Cell Signal       Date:  1990       Impact factor: 4.315

7.  Metabolism of inositol 1,3,4,5-tetrakisphosphate by human erythrocyte membranes. A new mechanism for the formation of inositol 1,4,5-trisphosphate.

Authors:  C Doughney; M A McPherson; R L Dormer
Journal:  Biochem J       Date:  1988-05-01       Impact factor: 3.857

8.  Degradation of inositol 1,3,4,5-tetrakisphosphates by porcine brain cytosol yields inositol 1,3,4-trisphosphate and inositol 1,4,5-trisphosphate.

Authors:  D Höer; A Kwiatkowski; C Seib; W Rosenthal; G Schultz; E Oberdisse
Journal:  Biochem Biophys Res Commun       Date:  1988-07-29       Impact factor: 3.575

9.  Formation of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate from inositol 1,3,4,5-tetrakisphosphate and their pathways of degradation in RBL-2H3 cells.

Authors:  J R Cunha-Melo; N M Dean; H Ali; M A Beaven
Journal:  J Biol Chem       Date:  1988-10-05       Impact factor: 5.157

10.  Metabolism of inositol bis-, tris-, tetrakis- and pentakis-phosphates in GH3 cells.

Authors:  N M Dean; J D Moyer
Journal:  Biochem J       Date:  1988-03-01       Impact factor: 3.857
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  6 in total

1.  Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo.

Authors:  H Chi; X Yang; P D Kingsley; R J O'Keefe; J E Puzas; R N Rosier; S B Shears; P R Reynolds
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

2.  Synthetic inositol 1,3,4,5-tetrakisphosphate analogues.

Authors:  M Hirata; Y Kimura; T Ishimatsu; F Yanaga; T Shuto; T Sasaguri; T Koga; Y Watanabe; S Ozaki
Journal:  Biochem J       Date:  1991-06-01       Impact factor: 3.857

3.  Comparison of the activities of a multiple inositol polyphosphate phosphatase obtained from several sources: a search for heterogeneity in this enzyme.

Authors:  A Craxton; N Ali; S B Shears
Journal:  Biochem J       Date:  1995-01-15       Impact factor: 3.857

4.  Inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate are inhibitors of the soluble inositol 1,3,4,5-tetrakisphosphate 3-phosphatase and the inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase from pig brain.

Authors:  A Höer; E Oberdisse
Journal:  Biochem J       Date:  1991-08-15       Impact factor: 3.857

5.  Electroporation can cause artefacts due to solubilization of cations from the electrode plates. Aluminum ions enhance conversion of inositol 1,3,4,5-tetrakisphosphate into inositol 1,4,5-trisphosphate in electroporated L1210 cells.

Authors:  J W Loomis-Husselbee; P J Cullen; R F Irvine; A P Dawson
Journal:  Biochem J       Date:  1991-08-01       Impact factor: 3.857

6.  Inositol polyphosphate metabolism and inositol lipids in a green alga, Chlamydomonas eugametos.

Authors:  R F Irvine; A J Letcher; L R Stephens; A Musgrave
Journal:  Biochem J       Date:  1992-01-01       Impact factor: 3.857
  6 in total

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