| Literature DB >> 21602373 |
Ghalia Kaci1, Omar Lakhdari, Joël Doré, S Dusko Ehrlich, Pierre Renault, Hervé M Blottière, Christine Delorme.
Abstract
Streptococcus salivarius exhibited an anti-inflammatory effect on intestinal epithelial cells (IECs) and monocytes. Strains were screened using a reporter clone, HT-29/kB-luc-E, induced by tumor necrosis factor alpha (TNF-α). Supernatant from each strain downregulated NF-κB activation. The two most efficient strains produced an active metabolite (<3 kDa) which was able to downregulate the secretion of the proinflammatory chemokine interleukin-8 (IL-8).Entities:
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Year: 2011 PMID: 21602373 PMCID: PMC3127691 DOI: 10.1128/AEM.03021-10
Source DB: PubMed Journal: Appl Environ Microbiol ISSN: 0099-2240 Impact factor: 4.792