BACKGROUND: Cytomegalovirus (CMV) is a pathogen and can cause life-threatening infection in the patients with malignancies. This study was conducted to investigate the risk factors and outcomes of CMV viremia in patients with malignancies. METHODS: Data were collected with retrospective analysis from adults suffering from CMV viremia with underlying malignancies. A total of 107 patients were enrolled in a tertiary medical center in northern Taiwan from March 2008 to December 2009. RESULTS: Among the 107 patients who suffered with CMV viremia with an overall mortality rate of 56.1% (60/107), 75 patients (70.1%) had solid organ malignancies and 32 (29.9%) had hematological malignancies. Mechanical ventilation (p=0.048), leukocytosis (p=0.004), and lack of appropriate early treatment (p=0.011) were independent predisposing factors associated with higher mortality rate. CONCLUSIONS: CMV viremia predicts high mortality rate in cancer patients, especially in those with mechanical ventilation, leukocytosis, and lack of appropriate early treatment. Appropriate early antiviral therapy is recommended to improve outcomes.
BACKGROUND: Cytomegalovirus (CMV) is a pathogen and can cause life-threatening infection in the patients with malignancies. This study was conducted to investigate the risk factors and outcomes of CMV viremia in patients with malignancies. METHODS: Data were collected with retrospective analysis from adults suffering from CMV viremia with underlying malignancies. A total of 107 patients were enrolled in a tertiary medical center in northern Taiwan from March 2008 to December 2009. RESULTS: Among the 107 patients who suffered with CMV viremia with an overall mortality rate of 56.1% (60/107), 75 patients (70.1%) had solid organ malignancies and 32 (29.9%) had hematological malignancies. Mechanical ventilation (p=0.048), leukocytosis (p=0.004), and lack of appropriate early treatment (p=0.011) were independent predisposing factors associated with higher mortality rate. CONCLUSIONS:CMV viremia predicts high mortality rate in cancerpatients, especially in those with mechanical ventilation, leukocytosis, and lack of appropriate early treatment. Appropriate early antiviral therapy is recommended to improve outcomes.
Authors: DeVon Hunter-Schlichting; Karl T Kelsey; Ryan Demmer; Manish Patel; Raphael Bueno; Brock Christensen; Naomi Fujioka; Deepa Kolarseri; Heather H Nelson Journal: PLoS One Date: 2021-08-12 Impact factor: 3.240
Authors: Konstantin Schlick; Michael Grundbichler; Jutta Auberger; Jan Marco Kern; Markus Hell; Florian Hohla; Georg Hopfinger; Richard Greil Journal: Infect Agent Cancer Date: 2015-12-03 Impact factor: 2.965
Authors: Jong An; Jason Brownell; Darrell Barker; Theresa Stockinger; Robert Brady; Katherine Cebe; Russell Baur Journal: Case Rep Oncol Med Date: 2018-03-20