| Literature DB >> 21601896 |
Kenn Foubert1, Filip Cuyckens, Ann Matheeussen, Arnold Vlietinck, Sandra Apers, Louis Maes, Luc Pieters.
Abstract
Bioassay-guided isolation was performed on the leaves of Apodytes dimidiata E. Mey. Ex Arn. (Icacinaceae), based on previously demonstrated activity against Leishmania. Six saponins never isolated from nature before were elucidated with LC-MS/MS, GC-MS and 1D and 2D NMR. The compounds apodytine A-F are responsible at least in part for the antiprotozoal activity, but also possess haemolytic activity and display antiangiogenic activity in the rat aorta ring assay, an effect which may be due to a non-selective toxicity.Entities:
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Year: 2011 PMID： 21601896 DOI： 10.1016/j.phytochem.2011.04.009
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072