Literature DB >> 21601572

Tyrphostin analogs are GPR35 agonists.

Huayun Deng1, Haibei Hu, Ye Fang.   

Abstract

GPR35 is an orphan G protein-coupled receptor that is not well-characterized. Here we employ dynamic mass redistribution (DMR) assays to discover new GPR35 agonists. DMR assays identified tyrphostin analogs as GPR35 agonists, which were confirmed with receptor internalization, Tango β-arrestin translocation, and extracellular-signal-regulated kinase phosphorylation assays. These agonists provide pharmacological tools to study the biology and function of GPR35.
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21601572     DOI： 10.1016/j.febslet.2011.05.026

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  16 in total

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2.  Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists.

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Journal:  ACS Med Chem Lett       Date:  2012-06-06       Impact factor: 4.345

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Authors:  Huayun Deng; Ye Fang
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2012-04-15       Impact factor: 3.000

5.  GPR35 as a Novel Therapeutic Target.

Authors:  A E Mackenzie; J E Lappin; D L Taylor; S A Nicklin; G Milligan
Journal:  Front Endocrinol (Lausanne)       Date:  2011-11-09       Impact factor: 5.555

6.  Label-free phenotypic profiling identified D-luciferin as a GPR35 agonist.

Authors:  Haibei Hu; Huayun Deng; Ye Fang
Journal:  PLoS One       Date:  2012-04-12       Impact factor: 3.240

7.  Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists.

Authors:  Huayun Deng; Haibei Hu; Mingqian He; Jieyu Hu; Weijun Niu; Ann M Ferrie; Ye Fang
Journal:  J Med Chem       Date:  2011-10-04       Impact factor: 7.446

8.  Multiple tyrosine metabolites are GPR35 agonists.

Authors:  Huayun Deng; Haibei Hu; Ye Fang
Journal:  Sci Rep       Date:  2012-04-20       Impact factor: 4.379

9.  Antagonists of GPR35 display high species ortholog selectivity and varying modes of action.

Authors:  Laura Jenkins; Nicholas Harries; Jennifer E Lappin; Amanda E MacKenzie; Zaynab Neetoo-Isseljee; Craig Southern; Edward G McIver; Stuart A Nicklin; Debra L Taylor; Graeme Milligan
Journal:  J Pharmacol Exp Ther       Date:  2012-09-11       Impact factor: 4.030

Review 10.  Not Only Immune Escape-The Confusing Role of the TRP Metabolic Pathway in Carcinogenesis.

Authors:  Iwona Kwiatkowska; Justyna Magdalena Hermanowicz; Alicja Przybyszewska-Podstawka; Dariusz Pawlak
Journal:  Cancers (Basel)       Date:  2021-05-28       Impact factor: 6.639
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