| Literature DB >> 2160147 |
M D Williams1, B J Cohen, A C Beddall, K J Pasi, P P Mortimer, F G Hill.
Abstract
The prevalence of antibody to human parvovirus B19 was determined in 86 children with congenital bleeding disorders. Forty-seven of 53 boys (89%) receiving non-heat-treated factor VIII or prothrombin complex concentrates were anti-B19 IgG positive compared with 38% of their age-matched controls and 48% of children treated with cryoprecipitate. Acute B19 virus infection occurred in 2 boys 3-4 weeks after they had received the same batch of commercial factor VIII concentrate. Of 11 susceptible children who had only received heat-treated National Health Service factor VIII concentrate (8Y), 1 acquired anti-B19 IgG. This suggests that 8Y heat-treated concentrate has a much reduced risk of transmitting B19 virus and, by implication, other less heat-stable viruses such as human immunodeficiency virus.Entities:
Mesh：
Substances：
Year: 1990 PMID： 2160147 DOI： 10.1111/j.1423-0410.1990.tb02086.x
Source DB: PubMed Journal: Vox Sang ISSN： 0042-9007 Impact factor: 2.144