Literature DB >> 21601453

Isotope-coded chemical reporter and acid-cleavable affinity reagents for monitoring protein sulfenic acids.

Thu H Truong1, Francisco J Garcia, Young Ho Seo, Kate S Carroll.   

Abstract

We have developed an approach that allows relative quantification of protein sulfenic acids using a pair of light and heavy isotope labled probes, DAz-2 and d(6)-DAz-2. In conjunction with a new complementary acid-cleavable linker, Yn-ACL, we demonstrate that tagged peptides are successfully labeled, enriched, and fully characterized by LC-MS/MS analysis. Overall, this method can be applied to map sites of cysteine oxidation and compare protein sulfenylation in normal and disease states. Published by Elsevier Ltd.

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Year:  2011        PMID： 21601453     DOI： 10.1016/j.bmcl.2011.04.115

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  27 in total

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Review 3.  Chemical approaches to detect and analyze protein sulfenic acids.

Authors:  Cristina M Furdui; Leslie B Poole
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Authors:  Nelmi O Devarie Baez; Julie A Reisz; Cristina M Furdui
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Review 6.  Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery.

Authors:  Candice E Paulsen; Kate S Carroll
Journal:  Chem Rev       Date:  2013-03-20       Impact factor: 60.622

7.  An immunochemical approach to detect oxidized protein tyrosine phosphatases using a selective C-nucleophile tag.

Authors:  Francisco J Garcia; Kate S Carroll
Journal:  Mol Biosyst       Date:  2016-05-24

8.  A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes.

Authors:  Jiang Qian; Revati Wani; Chananat Klomsiri; Leslie B Poole; Allen W Tsang; Cristina M Furdui
Journal:  Chem Commun (Camb)       Date:  2012-03-20       Impact factor: 6.222

Review 9.  Redox Signaling by Reactive Electrophiles and Oxidants.

Authors:  Saba Parvez; Marcus J C Long; Jesse R Poganik; Yimon Aye
Journal:  Chem Rev       Date:  2018-08-27       Impact factor: 60.622

10.  Chasing cysteine oxidative modifications: proteomic tools for characterizing cysteine redox status.

Authors:  Christopher I Murray; Jennifer E Van Eyk
Journal:  Circ Cardiovasc Genet       Date:  2012-10-01
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