BACKGROUND: We showed recently that elevated brain levels of the chemokine stromal cell-derived growth factor-1α (SDF-1α/CXCL12, a ligand for the human immunodeficiency virus [HIV] co-receptor CXCR4) diminish the antinociceptive effect of morphine, but failed to influence buprenorphine-induced antinociception. AIMS: Because the HIV-1 coat protein, glycoprotein 120 (gp120) T-tropic strain, binds to the same receptor as SDF-1α/CXCL12, the present experiments were designed to investigate the consequence of administering gp120 to rat brain on buprenorphine-induced antinociception in the 54°C hot plate test. For comparative purposes, the effect of gp120 on an equi-antinociceptive dose of methadone was also examined. METHODS: A sterilized stainless-steel C313G guide cannula was implanted into the periaqueductal grey (PAG), a brain region critical for the processing of pain signals, and a primary site of action of many analgesics. Rats were pretreated with gp120, administered into the PAG. RESULTS: The subsequent antinociception associated with methadone was diminished whereas buprenorphine-induced antinociception was unaffected. Buprenorphine thus appears to be a more effective analgesic than methadone in the presence of gp120 in the brain, a condition that is associated with HIV-related pain and infection. Published by Elsevier Ireland Ltd.
BACKGROUND: We showed recently that elevated brain levels of the chemokine stromal cell-derived growth factor-1α (SDF-1α/CXCL12, a ligand for the human immunodeficiency virus [HIV] co-receptor CXCR4) diminish the antinociceptive effect of morphine, but failed to influence buprenorphine-induced antinociception. AIMS: Because the HIV-1 coat protein, glycoprotein 120 (gp120) T-tropic strain, binds to the same receptor as SDF-1α/CXCL12, the present experiments were designed to investigate the consequence of administering gp120 to rat brain on buprenorphine-induced antinociception in the 54°C hot plate test. For comparative purposes, the effect of gp120 on an equi-antinociceptive dose of methadone was also examined. METHODS: A sterilized stainless-steelC313G guide cannula was implanted into the periaqueductal grey (PAG), a brain region critical for the processing of pain signals, and a primary site of action of many analgesics. Rats were pretreated with gp120, administered into the PAG. RESULTS: The subsequent antinociception associated with methadone was diminished whereas buprenorphine-induced antinociception was unaffected. Buprenorphine thus appears to be a more effective analgesic than methadone in the presence of gp120 in the brain, a condition that is associated with HIV-related pain and infection. Published by Elsevier Ireland Ltd.
Authors: E D Milligan; K K Mehmert; J L Hinde; L O Harvey; D Martin; K J Tracey; S F Maier; L R Watkins Journal: Brain Res Date: 2000-04-07 Impact factor: 3.252
Authors: Joseph Pergolizzi; Anna Maria Aloisi; Albert Dahan; Joerg Filitz; Richard Langford; Rudolf Likar; Sebastiano Mercadante; Bart Morlion; Robert B Raffa; Rainer Sabatowski; Paola Sacerdote; Luis M Torres; Avi A Weinbroum Journal: Pain Pract Date: 2010 Sep-Oct Impact factor: 3.183
Authors: Sylvia Fitting; Krista L Scoggins; Ruqiang Xu; Seth M Dever; Pamela E Knapp; William L Dewey; Kurt F Hauser Journal: Eur J Pharmacol Date: 2012-05-30 Impact factor: 4.432
Authors: R Douglas Bruce; Jessica Merlin; Paula J Lum; Ebtesam Ahmed; Carla Alexander; Amanda H Corbett; Kathleen Foley; Kate Leonard; Glenn Jordan Treisman; Peter Selwyn Journal: Clin Infect Dis Date: 2017-10-30 Impact factor: 9.079