BACKGROUND AND PURPOSE: To evaluate the accuracy of (11)C-choline PET scans in defining dominant intraprostatic lesions (DILs) for radiotherapy target volume definition. MATERIAL AND METHODS: Eight men with prostate cancer who had (11)C-choline PET scans prior to radical prostatectomy were studied. Several methods were used to contour the DIL on the PET scans: visual, PET Edge, Region Grow, absolute standardised uptake value (SUV) thresholds and percentage of maximum SUV thresholds. Prostatectomy specimens were sliced in the transverse plane and DILs were delineated on these by a pathologist. These were then compared with the PET scans. The accuracy of correlation was assessed by the Dice similarity coefficient (DSC) and the Youden index. RESULTS: The contouring method resulting in both the highest DSC and the highest Youden index was 60% of the maximum SUV (SUV(60%)), with values of 0.64 and 0.51, respectively. However SUV(60%) was not statistically significantly better than all of the other methods by either measure. CONCLUSIONS: Although not statistically significant, SUV(60%) resulted in the best correlation between (11)C-choline PET and pathology amongst all the methods studied. The degree of correlation shown here is consistent with previous studies that have justified using imaging for DIL radiotherapy target volume definition.
BACKGROUND AND PURPOSE: To evaluate the accuracy of (11)C-choline PET scans in defining dominant intraprostatic lesions (DILs) for radiotherapy target volume definition. MATERIAL AND METHODS: Eight men with prostate cancer who had (11)C-choline PET scans prior to radical prostatectomy were studied. Several methods were used to contour the DIL on the PET scans: visual, PET Edge, Region Grow, absolute standardised uptake value (SUV) thresholds and percentage of maximum SUV thresholds. Prostatectomy specimens were sliced in the transverse plane and DILs were delineated on these by a pathologist. These were then compared with the PET scans. The accuracy of correlation was assessed by the Dice similarity coefficient (DSC) and the Youden index. RESULTS: The contouring method resulting in both the highest DSC and the highest Youden index was 60% of the maximum SUV (SUV(60%)), with values of 0.64 and 0.51, respectively. However SUV(60%) was not statistically significantly better than all of the other methods by either measure. CONCLUSIONS: Although not statistically significant, SUV(60%) resulted in the best correlation between (11)C-choline PET and pathology amongst all the methods studied. The degree of correlation shown here is consistent with previous studies that have justified using imaging for DIL radiotherapy target volume definition.
Authors: Tony Shepherd; Mika Teras; Reinhard R Beichel; Ronald Boellaard; Michel Bruynooghe; Volker Dicken; Mark J Gooding; Peter J Julyan; John A Lee; Sébastien Lefèvre; Michael Mix; Valery Naranjo; Xiaodong Wu; Habib Zaidi; Ziming Zeng; Heikki Minn Journal: IEEE Trans Med Imaging Date: 2012-06-04 Impact factor: 10.048
Authors: Cédric Draulans; Robin De Roover; Uulke A van der Heide; Linda Kerkmeijer; Robert J Smeenk; Floris Pos; Wouter V Vogel; James Nagarajah; Marcel Janssen; Sofie Isebaert; Frederik Maes; Cindy Mai; Raymond Oyen; Steven Joniau; Martina Kunze-Busch; Karolien Goffin; Karin Haustermans Journal: Eur J Nucl Med Mol Imaging Date: 2020-10-06 Impact factor: 9.236
Authors: Anca-Ligia Grosu; Gregor Weirich; Christina Wendl; Vesna Prokic; Simon Kirste; Hans Geinitz; Michael Souvatzoglou; Juergen E Gschwend; Markus Schwaiger; Michael Molls; Wolfgang A Weber; Uwe Treiber; Bernd Joachim Krause Journal: Eur J Nucl Med Mol Imaging Date: 2014-09-04 Impact factor: 9.236
Authors: L Van den Bergh; S Isebaert; M Koole; R Oyen; S Joniau; E Lerut; C M Deroose; F De Keyzer; H Van Poppel; K Haustermans Journal: Strahlenther Onkol Date: 2013-09 Impact factor: 3.621
Authors: Joe H Chang; Daryl Lim Joon; Sze Ting Lee; Chee-Yan Hiew; Stephen Esler; Sylvia J Gong; Morikatsu Wada; David Clouston; Richard O'Sullivan; Yin P Goh; Henri Tochon-Danguy; J Gordon Chan; Damien Bolton; Andrew M Scott; Vincent Khoo; Ian D Davis Journal: Eur Radiol Date: 2013-11-06 Impact factor: 5.315
Authors: Constantinos Zamboglou; Gesche Wieser; Steffen Hennies; Irene Rempel; Simon Kirste; Martin Soschynski; Hans Christian Rischke; Tobias Fechter; Cordula A Jilg; Mathias Langer; Philipp T Meyer; Michael Bock; Anca-Ligia Grosu Journal: Eur J Nucl Med Mol Imaging Date: 2015-11-23 Impact factor: 9.236
Authors: S M Schwarzenböck; J Kurth; Ch Gocke; T Kuhnt; G Hildebrandt; B J Krause Journal: Eur J Nucl Med Mol Imaging Date: 2013-04-11 Impact factor: 9.236