Jane L Harman1, Michael E Griswold2, Neal O Jeffries3, Anne E Sumner4, Daniel F Sarpong5, Ermeg L Akylbekova5, Evelyn R Walker6, Sharon B Wyatt7, Herman A Taylor8. 1. Program in Prevention and Population Sciences, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Suite 10018, Bethesda, MD 20982-7936, USA. Electronic address: harmanj@mail.nih.gov. 2. University of Mississippi Medical Center, Jackson, MS, Jackson, MS, USA. 3. Office of Biostatistics Research, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. 4. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. 5. Jackson State University, Jackson, MS, USA. 6. Program in Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD, USA. 7. University of Mississippi Medical Center, Jackson, MS, USA. 8. Jackson State University, Jackson, MS, USA; University of Mississippi Medical Center, Jackson, MS, USA; Tougaloo College, Tougaloo, MS, USA.
Abstract
BACKGROUND: African Americans have historically had high high-density lipoprotein cholesterol (HDL-C) compared with other races and ethnicities. OBJECTIVE: We sought to characterize whether there is a cross-sectional association between age and HDL-C in a contemporary community-based study of African Americans. METHODS: Cross-sectional data were modeled by logistic regression for predictors of HDL-C among African Americans, ages 35-74, participating in the baseline examination of a community-based study of cardiovascular disease in Jackson, Mississippi, during 2000-2004. After excluding persons taking lipid-lowering medications, hormone replacement therapy, oral contraceptives, or thyroid replacement, the analytical data set comprised 2420 persons (1370 women, 1050 men). RESULTS: HDL-C had a significant positive association with age after controlling for serum triglycerides, sex, waist circumference, percent dietary calories from carbohydrates, alcohol use, and leisure physical activity. Sex was a significant effect modifier of this relationship, whereby the increase in HDL-C with age was steeper for women than for men. CONCLUSIONS: Cross-sectional analysis found a positive association of HDL-C with age while controlling for triglycerides. Careful evaluation of longitudinal data will be needed to confirm whether this is a true effect of aging, or a cohort or survivor effect. Published by Elsevier Inc.
BACKGROUND: African Americans have historically had high high-density lipoprotein cholesterol (HDL-C) compared with other races and ethnicities. OBJECTIVE: We sought to characterize whether there is a cross-sectional association between age and HDL-C in a contemporary community-based study of African Americans. METHODS: Cross-sectional data were modeled by logistic regression for predictors of HDL-C among African Americans, ages 35-74, participating in the baseline examination of a community-based study of cardiovascular disease in Jackson, Mississippi, during 2000-2004. After excluding persons taking lipid-lowering medications, hormone replacement therapy, oral contraceptives, or thyroid replacement, the analytical data set comprised 2420 persons (1370 women, 1050 men). RESULTS: HDL-C had a significant positive association with age after controlling for serum triglycerides, sex, waist circumference, percent dietary calories from carbohydrates, alcohol use, and leisure physical activity. Sex was a significant effect modifier of this relationship, whereby the increase in HDL-C with age was steeper for women than for men. CONCLUSIONS: Cross-sectional analysis found a positive association of HDL-C with age while controlling for triglycerides. Careful evaluation of longitudinal data will be needed to confirm whether this is a true effect of aging, or a cohort or survivor effect. Published by Elsevier Inc.
Authors: J A Morrison; I deGroot; K A Kelly; M J Mellies; P Khoury; B K Edwards; D Lewis; A Lewis; M Fiorelli; G Heiss; H A Tyroler; C J Glueck Journal: Prev Med Date: 1979-01 Impact factor: 4.018