Literature DB >> 21600311

Toll-like receptors in inflammation of the central nervous system.

Yan Kong1, Yingying Le.   

Abstract

Toll-like receptors (TLRs) belong to pattern-recognition receptor family that could recognize exogenous pathogen-associated molecular patterns and endogenous damage-associated molecular patterns. TLRs play pivotal roles in innate and adaptive immune responses. In this review we summarize the ligands and signal transduction pathways of TLRs and highlight recent progress of the involvement of TLRs in neuroinflammation related disorders, including cerebral ischemia/stroke, brain trauma and hemorrhage, pathogen infection and autoimmune diseases, and explore the potential of TLR signaling as therapeutic targets against these disorders.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21600311     DOI： 10.1016/j.intimp.2011.04.025

Source DB:  PubMed          Journal:  Int Immunopharmacol        ISSN： 1567-5769            Impact factor:   4.932


  53 in total

Review 1.  Bridge between neuroimmunity and traumatic brain injury.

Authors:  Matthew L Kelso; Howard E Gendelman
Journal:  Curr Pharm Des       Date:  2014       Impact factor: 3.116

Review 2.  Inflammatory responses in brain ischemia.

Authors:  Masahito Kawabori; Midori A Yenari
Journal:  Curr Med Chem       Date:  2015       Impact factor: 4.530

3.  Toll-like receptors and diseases.

Authors:  Pablo Iribarren; Ji Ming Wang
Journal:  Int Immunopharmacol       Date:  2011-08-30       Impact factor: 4.932

Review 4.  Understanding the Role of Innate Immunity in the Response to Intracortical Microelectrodes.

Authors:  John K Hermann; Jeffrey R Capadona
Journal:  Crit Rev Biomed Eng       Date:  2018

Review 5.  The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies.

Authors:  Anna Warden; Emma Erickson; Gizelle Robinson; R Adron Harris; R Dayne Mayfield
Journal:  Pharmacogenomics       Date:  2016-12-05       Impact factor: 2.533

6.  Sparstolonin B improves neurological outcomes following intracerebral hemorrhage in mice.

Authors:  Yanchun Wang; Side Jiang; Jing Xiao; Qiaoli Liang; Mingshan Tang
Journal:  Exp Ther Med       Date:  2018-04-24       Impact factor: 2.447

7.  Toll-Like Receptor-3 Mediates HIV-1-Induced Interleukin-6 Expression in the Human Brain Endothelium via TAK1 and JNK Pathways: Implications for Viral Neuropathogenesis.

Authors:  Biju Bhargavan; Georgette D Kanmogne
Journal:  Mol Neurobiol       Date:  2017-11-11       Impact factor: 5.590

8.  Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia.

Authors:  Xi Lan; Xiaoning Han; Qian Li; Qiang Li; Yufeng Gao; Tian Cheng; Jieru Wan; Wei Zhu; Jian Wang
Journal:  Brain Behav Immun       Date:  2016-12-20       Impact factor: 7.217

9.  Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance.

Authors:  John K Hermann; Madhumitha Ravikumar; Andrew J Shoffstall; Evon S Ereifej; Kyle M Kovach; Jeremy Chang; Arielle Soffer; Chun Wong; Vishnupriya Srivastava; Patrick Smith; Grace Protasiewicz; Jingle Jiang; Stephen M Selkirk; Robert H Miller; Steven Sidik; Nicholas P Ziats; Dawn M Taylor; Jeffrey R Capadona
Journal:  J Neural Eng       Date:  2018-04       Impact factor: 5.379

Review 10.  Anti-angiogenic gene therapy in the treatment of malignant gliomas.

Authors:  NaTosha N Gatson; E Antonio Chiocca; Balveen Kaur
Journal:  Neurosci Lett       Date:  2012-08-10       Impact factor: 3.046
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