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Literature DB >> 21600224

Genetics of leukocyte telomere length and its role in atherosclerosis.

Abstract

Humans display a large inter-individual variation in leukocyte telomere length (LTL), which is influenced by heredity, sex, race/ethnicity, paternal age at conception and environmental exposures. LTL dynamics (birth LTL and its age-dependent attrition thereafter) mirror telomere dynamics in hematopoietic stem cells (HSCs). LTL at birth is evidently a major determinant of LTL throughout the human lifespan, such that individuals endowed with short (or long) LTL at birth probably have short (or long) LTL later in life. Therefore, the associations of short LTL with atherosclerosis and with diminished survival in the elderly may relate to short birth LTL, accelerated age-dependent LTL attrition, or both. The mechanisms underlying these associations are still not well understood, but they stem in part from genetic factors in control of telomere maintenance and the rate of HSC replication.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2011 PMID： 21600224 PMCID： PMC3202050 DOI： 10.1016/j.mrfmmm.2011.05.001

Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433

132 in total

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Journal: Am J Hum Genet Date: 2004-11-01 Impact factor: 11.025

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Journal: Dev Genet Date: 1996

5. Telomere length and genetic analyses in population-based studies of endometrial cancer risk.

Authors: Jennifer Prescott; Monica McGrath; I-Min Lee; Julie E Buring; Immaculata De Vivo
Journal: Cancer Date: 2010-09-15 Impact factor: 6.860

Review 6. Heart disease and aging.

Authors: Wilbert S Aronow
Journal: Med Clin North Am Date: 2006-09 Impact factor: 5.456

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Authors: Athanase Benetos; Jeffrey P Gardner; Mahmoud Zureik; Carlos Labat; Lu Xiaobin; Chris Adamopoulos; Mohamed Temmar; Kathryn E Bean; Frédérique Thomas; Abraham Aviv
Journal: Hypertension Date: 2004-01-19 Impact factor: 10.190

8. Coronary calcium as a predictor of coronary events in four racial or ethnic groups.

Authors: Robert Detrano; Alan D Guerci; J Jeffrey Carr; Diane E Bild; Gregory Burke; Aaron R Folsom; Kiang Liu; Steven Shea; Moyses Szklo; David A Bluemke; Daniel H O'Leary; Russell Tracy; Karol Watson; Nathan D Wong; Richard A Kronmal
Journal: N Engl J Med Date: 2008-03-27 Impact factor: 91.245

9. Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: the Framingham Heart Study.

Authors: Ramachandran S Vasan; Serkalem Demissie; Masayuki Kimura; L Adrienne Cupples; Nader Rifai; Charles White; Thomas J Wang; Jeffrey P Gardner; Xiaogian Cao; Emelia J Benjamin; Daniel Levy; Abraham Aviv
Journal: Circulation Date: 2008-02-11 Impact factor: 29.690

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Authors: Ramin Farzaneh-Far; Jue Lin; Elissa Epel; Kyle Lapham; Elizabeth Blackburn; Mary A Whooley
Journal: PLoS One Date: 2010-01-08 Impact factor: 3.240

60 in total

Review 1. Telomerase and idiopathic pulmonary fibrosis.

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Journal: Mutat Res Date: 2011-11-04 Impact factor: 2.433

Review 2. The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance.

Authors: Jonathan H Teichroeb; Joohwan Kim; Dean H Betts
Journal: RNA Biol Date: 2016-01-19 Impact factor: 4.652

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Authors: Rodrigo T Calado; Bogdan Dumitriu
Journal: Semin Hematol Date: 2013-04 Impact factor: 3.851

Review 4. The impact of hypertension on leukocyte telomere length: a systematic review and meta-analysis of human studies.

Authors: M L Tellechea; C J Pirola
Journal: J Hum Hypertens Date: 2016-06-30 Impact factor: 3.012

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Authors: Daniel Lindqvist; Elissa S Epel; Synthia H Mellon; Brenda W Penninx; Dóra Révész; Josine E Verhoeven; Victor I Reus; Jue Lin; Laura Mahan; Christina M Hough; Rebecca Rosser; F Saverio Bersani; Elizabeth H Blackburn; Owen M Wolkowitz
Journal: Neurosci Biobehav Rev Date: 2015-05-18 Impact factor: 8.989

6. Telomere-associated polymorphisms correlate with cardiovascular disease mortality in Caucasian women: the Cardiovascular Health Study.

Authors: Andrea N Burnett-Hartman; Annette L Fitzpatrick; Richard A Kronmal; Bruce M Psaty; Nancy S Jenny; Josh C Bis; Russ P Tracy; Masayuki Kimura; Abraham Aviv
Journal: Mech Ageing Dev Date: 2012-03-16 Impact factor: 5.432

10. Lifespan adversity and later adulthood telomere length in the nationally representative US Health and Retirement Study.

Authors: Eli Puterman; Alison Gemmill; Deborah Karasek; David Weir; Nancy E Adler; Aric A Prather; Elissa S Epel
Journal: Proc Natl Acad Sci U S A Date: 2016-10-03 Impact factor: 11.205