| Literature DB >> 21598112 |
Xinbing Sui1, Da Wang, Shumin Geng, Gongli Zhou, Chao He, Xiaotong Hu.
Abstract
Protocadherins are a major subfamily of the cadherin superfamily. Their functions and intracellular signal transduction are poorly understood, although some have been explored in nervous system development. However, recent researches have shown that protocadherins frequently act as tumor suppressor genes (TSGs) and inactivation of these genes through promoter methylation is closely correlated with tumor development. Furthermore, these methylated protocadherins may serve as tumor biomarkers in various body fluids, stool and scrapings not only for early cancer diagnosis, but also for assessing prognosis and monitoring response to therapy. Thus, methylated promoters of genes encoding protocadherins show promise as a new cancer biomarker family.Entities:
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Year: 2011 PMID： 21598112 DOI： 10.1007/s11033-011-0837-8
Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316