CASE PRESENTATION: A 54-year-old male patient presenting probable multiple system atrophy with predominant parkinsonism who underwent bilateral deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is presented. The patient had dominant freezing of gait (FOG), levodopa-resistant bradykinesia, and autonomic disturbances, but with a good cognitive condition. METHODS: The patient underwent bilateral DBS of the PPN, which ended with modest benefits. RESULTS AND CONCLUSION: Although he had a short postoperative follow-up (6 months), his neurological status remained stable and PPN DBS provided modest improvements in the gait disorder and freezing episodes. This unusual case suggests that the mesencephalic pedunculopontine region may have a role in locomotor symptoms and the potential to provide a limited improvement in FOG.
CASE PRESENTATION: A 54-year-old male patient presenting probable multiple system atrophy with predominant parkinsonism who underwent bilateral deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is presented. The patient had dominant freezing of gait (FOG), levodopa-resistant bradykinesia, and autonomic disturbances, but with a good cognitive condition. METHODS: The patient underwent bilateral DBS of the PPN, which ended with modest benefits. RESULTS AND CONCLUSION: Although he had a short postoperative follow-up (6 months), his neurological status remained stable and PPN DBS provided modest improvements in the gait disorder and freezing episodes. This unusual case suggests that the mesencephalic pedunculopontine region may have a role in locomotor symptoms and the potential to provide a limited improvement in FOG.
Authors: Rene Molina; Chris J Hass; Stephanie Cernera; Kristen Sowalsky; Abigail C Schmitt; Jaimie A Roper; Daniel Martinez-Ramirez; Enrico Opri; Christopher W Hess; Robert S Eisinger; Kelly D Foote; Aysegul Gunduz; Michael S Okun Journal: Front Hum Neurosci Date: 2021-03-01 Impact factor: 3.169
Authors: Shenghong He; Alceste Deli; Petra Fischer; Christoph Wiest; Yongzhi Huang; Sean Martin; Saed Khawaldeh; Tipu Z Aziz; Alexander L Green; Peter Brown; Huiling Tan Journal: J Neurosci Date: 2021-08-19 Impact factor: 6.167