Literature DB >> 2159661

Diacylglycerol kinase: a key modulator of signal transduction?

H Kanoh1, K Yamada, F Sakane.   

Abstract

Diacylglycerol kinase (DGK) plays a central role in the metabolism of diacylglycerol released as a second messenger in agonist-stimulated cells. The major purified form of the enzyme (80 kDa DGK) is highly abundant in lymphocyte cytosol and may become membrane-associated via phosphorylation by protein kinase C. In addition, there are several kinase subspecies immunologically distinct from the 80 kDa enzyme, which differ markedly in their responses to several compounds such as sphingosine and R59022. Thus, further work on each enzyme species is needed to define the function of DGK in stimulated cells.

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Year:  1990        PMID： 2159661     DOI： 10.1016/0968-0004(90)90172-8

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  47 in total

1.  Effects of NMDA on carbachol-stimulated phosphatidylinositol resynthesis in rat brain cortical slices.

Authors:  H M Lee; C L Huang
Journal:  Neurochem Res       Date:  1997-05       Impact factor: 3.996

2.  Novel diacylglycerol kinase inhibitor selectively suppressed an U46619-induced enhancement of mouse portal vein contraction under high glucose conditions.

Authors:  Koji Nobe; Mari Miyatake; Hiromi Nobe; Yasushi Sakai; Junko Takashima; Kazutaka Momose
Journal:  Br J Pharmacol       Date:  2004-08-02       Impact factor: 8.739

3.  The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain.

Authors:  Shin-Ichi Imai; Masahiro Kai; Keiko Yamada; Hideo Kanoh; Fumio Sakane
Journal:  Biochem J       Date:  2004-09-15       Impact factor: 3.857

4.  Evaluation of human diacylglycerol kinase(iota), DGKI, a homolog of Drosophila rdgA, in inherited retinopathy mapping to 7q.

Authors:  S J Bowne; L S Sullivan; L Ding; E Traer; S M Prescott; D G Birch; A Kennan; P Humphries; S P Daiger
Journal:  Mol Vis       Date:  2000-02-22       Impact factor: 2.367

5.  Diacylglycerol kinase from suspension cultured plant cells : characterization and subcellular localization.

Authors:  J B Wissing; K G Wagner
Journal:  Plant Physiol       Date:  1992-03       Impact factor: 8.340

6.  Effect of R59022, an inhibitor of diacylglycerol kinase, on IgE-mediated histamine release from human lung mast cells and basophils.

Authors:  K L O'Keefe; J A Warner
Journal:  Agents Actions       Date:  1994-11

7.  Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons.

Authors:  K Goto; H Kondo
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-15       Impact factor: 11.205

8.  Intracellular calcium mobilization and phospholipid degradation in sphingosylphosphorylcholine-stimulated human airway epithelial cells.

Authors:  S Orlati; A M Porcelli; S Hrelia; A Lorenzini; M Rugolo
Journal:  Biochem J       Date:  1998-09-15       Impact factor: 3.857

9.  Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12.

Authors:  T C Hart; C Champagne; J Zhou; T E Van Dyke
Journal:  Mamm Genome       Date:  1994-02       Impact factor: 2.957

10.  Requirement for diacylglycerol and protein kinase C in HeLa cell-substratum adhesion and their feedback amplification of arachidonic acid production for optimum cell spreading.

Authors:  J S Chun; B S Jacobson
Journal:  Mol Biol Cell       Date:  1993-03       Impact factor: 4.138
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