| Literature DB >> 21596598 |
W Coura-Vital1, M J Marques2, R C Giunchetti3, A Teixeira-Carvalho4, N D Moreira5, J Vitoriano-Souza5, P M Vieira5, C M Carneiro5, R Corrêa-Oliveira6, O A Martins-Filho4, M Carneiro7, A B Reis8.
Abstract
Molecular analysis, serology and immunophenotyping for T lymphocytes and their subsets, B lymphocytes and monocytes were performed on dogs naturally infected with Leishmania infantum. Animals were categorised as asymptomatic dogs I (AD-I), with negative serology and positive molecular results, and asymptomatic dogs II (AD-II), with positive serology and positive molecular results, and these were compared to symptomatic dogs (SD) and control dogs (CD). AD-I exhibited immunophenotypic features similar to those of CD, including isotype profiles and concentrations of monocytes. Similar biomarkers were found in AD-II and SD, such as, higher levels of immunoglobulins IgG, IgG2, IgM and IgA and higher concentrations of eosinophils. High frequencies of T lymphocytes and CD4(+) T cells were observed in both AD-I and AD-II compared to SD, whereas CD8(+) T cells were higher only in AD-II compared with SD. Analysis of B lymphocytes revealed an increased frequency of this cell type only in AD-II animals compared with SD. Asymptomatic dogs appear to have a dichotomous infection spectrum that can influence the humoral and cellular immunological status during canine visceral leishmaniasis.Entities:
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Year: 2011 PMID： 21596598 DOI： 10.1016/j.tvjl.2011.04.005
Source DB: PubMed Journal: Vet J ISSN： 1090-0233 Impact factor: 2.688