Ko-Wei Lin1, Jinghong Li, Patricia W Finn. 1. Division of Pulmonary and critical Care Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Abstract
BACKGROUND: Allergic asthma is a complex and chronic airway inflammatory disorder, and the prevalence of asthma has increased. Adaptive antigen-dependent immunity is a classical pathway of asthmatic pathology. Recent studies have focused on innate antigen-independent immunity in asthma. SCOPE OF REVIEW: This review discusses updated research associating innate immunity with allergic asthma. We focus on innate molecules (Toll-like receptors and nucleotide-binding oligomerization domain-like receptors) and review studies regarding innate and adaptive interactions in allergic responses (surfactant protein D, lipopolysaccharide, and early life immune responses). We also highlight new emerging concepts in the field applicable to innate immunity and asthma. MAJOR CONCLUSIONS: Innate immunity plays a key role in asthma. Understanding innate and adaptive interactions provide significant information in asthmatic research. Innate molecules not only contribute to classical pulmonary defense, but also modulate inflammatory responses. Emerging concepts in the analysis of the microbiome, microRNA and autophagy may provide new insights in searching therapeutic targets. GENERAL SIGNIFICANCE: Finding specific mechanisms of innate and/or adaptive immunity in asthma are timely goals for further research. Integration of bioinformatics and systems biology tools, particularly in relation to microbiome analysis, may be helpful in providing an understanding to allergic immune responses. This article is part of a Special Issue entitled Biochemistry of Asthma. 2011. Published by Elsevier B.V.
BACKGROUND:Allergic asthma is a complex and chronic airway inflammatory disorder, and the prevalence of asthma has increased. Adaptive antigen-dependent immunity is a classical pathway of asthmatic pathology. Recent studies have focused on innate antigen-independent immunity in asthma. SCOPE OF REVIEW: This review discusses updated research associating innate immunity with allergic asthma. We focus on innate molecules (Toll-like receptors and nucleotide-binding oligomerization domain-like receptors) and review studies regarding innate and adaptive interactions in allergic responses (surfactant protein D, lipopolysaccharide, and early life immune responses). We also highlight new emerging concepts in the field applicable to innate immunity and asthma. MAJOR CONCLUSIONS: Innate immunity plays a key role in asthma. Understanding innate and adaptive interactions provide significant information in asthmatic research. Innate molecules not only contribute to classical pulmonary defense, but also modulate inflammatory responses. Emerging concepts in the analysis of the microbiome, microRNA and autophagy may provide new insights in searching therapeutic targets. GENERAL SIGNIFICANCE: Finding specific mechanisms of innate and/or adaptive immunity in asthma are timely goals for further research. Integration of bioinformatics and systems biology tools, particularly in relation to microbiome analysis, may be helpful in providing an understanding to allergic immune responses. This article is part of a Special Issue entitled Biochemistry of Asthma. 2011. Published by Elsevier B.V.
Authors: Ayse Bilge Ozturk; Benjamin Arthur Turturice; David L Perkins; Patricia W Finn Journal: Curr Allergy Asthma Rep Date: 2017-08-10 Impact factor: 4.806
Authors: H Dean Hosgood; Amy R Sapkota; Nathaniel Rothman; Thomas Rohan; Wei Hu; Jun Xu; Roel Vermeulen; Xingzhou He; James Robert White; Guoping Wu; Fusheng Wei; Emmanuel F Mongodin; Qing Lan Journal: Environ Mol Mutagen Date: 2014-06-03 Impact factor: 3.216