[Effects of GIP receptor antagonist for treatment of obesity].

Glucose-dependent insulinotropic polypeptide(GIP) has been known as a peptide hormone with the effects not only of the augmentation of glucose induced insulin secretion but of the fat accumulation in adipocytes, of the bone formation and of the modulation of brain function. As indicated in GIP receptor deficient experimental animals, GIP receptor antagonists possess favorable effects such as, decreased body adiposity or improvement of glucose intolerance through change of fat metabolism in high-fat diet induced or genetically induced obese experimental animals. This review principally focused on these preclinical data of GIP receptor antagonism.