| Literature DB >> 2159413 |
T Johansen1, T Knudsen, H Bertelsen.
Abstract
The effect of EGTA on the enhancement by ouabain of compound 48/80-induced secretion from mast cells was compared with the effect on the Na(+)-K+ pump activity. The time-dependent secretory enhancement by ouabain was blocked by addition of EGTA to the cell suspension concomitantly with the addition of ouabain, and EGTA caused a large increase in the pump activity. Addition of 10 microM EGTA to ouabain-treated cells stopped but did not reverse the enhancement. The experiments show that the effect of ouabain was due to changes in a calcium pool utilized in compound 48/80-induced secretion following changes in the Na+,K+ pump activity.Entities:
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Year: 1990 PMID： 2159413 DOI： 10.1016/0014-5793(90)80196-p
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124