Literature DB >> 2159411

Fluoride is a strong and specific inhibitor of (asymmetrical) Ap4A hydrolases.

A Guranowski1.   

Abstract

Fluoride acts as a noncompetitive, strong inhibitor of (asymmetrical) Ap4A hydrolases (EC 3.6.1.17). The Ki values estimated for the enzymes isolated from seeds of some higher plants (yellow lupin, sunflower and marrow) are in the range of 2-3 microM and I50 for the hydrolase from a mammalian tissue (beef liver) is 20 microM. The anion, up to 25 mM, does not affect the following other enzymes which are able to degrade the bis(5'-nucleosidyl)-oligophosphates: Escherichia coli (symmetrical) Ap4A hydrolase (EC 3.6.1.41), yeast Ap4A phosphorylase (EC 2.7.7.53), yellow lupin Ap3A hydrolase (EC 3.6.1.29) and phosphodiesterase (EC 3.1.4.1). None of halogenic anions but fluoride affects the activity of (asymmetrical) Ap4A hydrolases. Usefulness of the fluoride effect for the in vivo studies on the Ap4A metabolism is shortly discussed.

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Year:  1990        PMID： 2159411     DOI： 10.1016/0014-5793(90)80190-t

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

1.  Characterization of active-site residues in diadenosine tetraphosphate hydrolase from Lupinus angustifolius.

Authors:  D Maksel; P R Gooley; J D Swarbrick; A Guranowski; C Gange; G M Blackburn; K R Gayler
Journal:  Biochem J       Date:  2001-07-15       Impact factor: 3.857

2.  Diadenosine polyphosphate hydrolase from presynaptic plasma membranes of Torpedo electric organ.

Authors:  J Mateo; P Rotllan; E Marti; I Gomez De Aranda; C Solsona; M T Miras-Portugal
Journal:  Biochem J       Date:  1997-05-01       Impact factor: 3.857

3.  Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif.

Authors:  L Gasmi; J L Cartwright; A G McLennan
Journal:  Biochem J       Date:  1999-12-01       Impact factor: 3.857

4.  Adenosine 5'-tetraphosphate phosphohydrolase from yellow lupin seeds: purification to homogeneity and some properties.

Authors:  A Guranowski; E Starzyńska; P Brown; G M Blackburn
Journal:  Biochem J       Date:  1997-11-15       Impact factor: 3.857

5.  Cloning and expression of diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase from Lupinus angustifolius L.

Authors:  D Maksel; A Guranowski; S C Ilgoutz; A Moir; M G Blackburn; K R Gayler
Journal:  Biochem J       Date:  1998-01-15       Impact factor: 3.857

6.  The green alga Scenedesmus obliquus contains both diadenosine 5',5'''-P1,P4-tetraphosphate (asymmetrical) pyrophosphohydrolase and phosphorylase activities.

Authors:  A G McLennan; E Mayers; S Hankin; N M Thorne; M Prescott; R Powls
Journal:  Biochem J       Date:  1994-05-15       Impact factor: 3.857

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Journal:  Prog Lipid Res       Date:  2020-03-29       Impact factor: 16.195

Review 8.  New Insight into Plant Signaling: Extracellular ATP and Uncommon Nucleotides.

Authors:  Małgorzata Pietrowska-Borek; Jędrzej Dobrogojski; Ewa Sobieszczuk-Nowicka; Sławomir Borek
Journal:  Cells       Date:  2020-02-02       Impact factor: 6.600

9.  Identification of functional domains in Arabidopsis thaliana mRNA decapping enzyme (AtDcp2).

Authors:  Dilantha Gunawardana; Heung-Chin Cheng; Kenwyn R Gayler
Journal:  Nucleic Acids Res       Date:  2007-11-19       Impact factor: 16.971

10.  Principles of RNA and nucleotide discrimination by the RNA processing enzyme RppH.

Authors:  Ang Gao; Nikita Vasilyev; Abhishek Kaushik; Wenqian Duan; Alexander Serganov
Journal:  Nucleic Acids Res       Date:  2020-04-17       Impact factor: 16.971
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