| Literature DB >> 21592982 |
Duane L Pierson1, Satish K Mehta, Don Gilden, Randall J Cohrs, Maria A Nagel, D Scott Schmid, Stephen K Tyring.
Abstract
Analysis of 36 individuals over age 60 years who were immunized with Zostavax revealed varicella zoster virus (VZV) DNA in swabs of skin inoculation sites obtained immediately after immunization in 18 (50%) of 36 subjects (copy number per nanogram of total DNA, 28 to 2.1 × 10(6)) and in saliva collected over 28 days in 21 (58%) of 36 subjects (copy number, 20 to 248). Genotypic analysis of DNA extracted from 9 random saliva samples identified vaccine virus in all instances. In some immunized individuals over age 60, vaccine virus DNA is shed in saliva up to 4 weeks.Entities:
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Year: 2011 PMID: 21592982 PMCID: PMC3096786 DOI: 10.1093/infdis/jir139
Source DB: PubMed Journal: J Infect Dis ISSN: 0022-1899 Impact factor: 5.226