OBJECTIVE: The neurodevelopmental-neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it. METHODS: Fifteen patients (age range 23-42 years) matching DSM IV-TR criteria for SCH, and 15 sex- and age-matched control subjects (age range 23-42 years) underwent a resting-state magnetoencephalographic evaluation and Lempel-Ziv complexity (LZC) scores were calculated. RESULTS: Regression analyses indicated that LZC values were strongly dependent on age. Complexity scores increased as a function of age in controls, while SCH patients exhibited a progressive reduction of LZC values. A logistic model including LZC scores, age and the interaction of both variables allowed the classification of patients and controls with high sensitivity and specificity. CONCLUSIONS: Results demonstrated that SCH patients failed to follow the "normal" process of complexity increase as a function of age. In addition, SCH patients exhibited a significant reduction of complexity scores as a function of age, thus paralleling the pattern observed in neurodegenerative diseases. SIGNIFICANCE: Our results support the notion of a progressive defect in SCH, which does not contradict the existence of a basic neurodevelopmental alteration.
OBJECTIVE: The neurodevelopmental-neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it. METHODS: Fifteen patients (age range 23-42 years) matching DSM IV-TR criteria for SCH, and 15 sex- and age-matched control subjects (age range 23-42 years) underwent a resting-state magnetoencephalographic evaluation and Lempel-Ziv complexity (LZC) scores were calculated. RESULTS: Regression analyses indicated that LZC values were strongly dependent on age. Complexity scores increased as a function of age in controls, while SCH patients exhibited a progressive reduction of LZC values. A logistic model including LZC scores, age and the interaction of both variables allowed the classification of patients and controls with high sensitivity and specificity. CONCLUSIONS: Results demonstrated that SCH patients failed to follow the "normal" process of complexity increase as a function of age. In addition, SCH patients exhibited a significant reduction of complexity scores as a function of age, thus paralleling the pattern observed in neurodegenerative diseases. SIGNIFICANCE: Our results support the notion of a progressive defect in SCH, which does not contradict the existence of a basic neurodevelopmental alteration.
Authors: Jose A Cortes-Briones; John D Cahill; Patrick D Skosnik; Daniel H Mathalon; Ashley Williams; R Andrew Sewell; Brian J Roach; Judith M Ford; Mohini Ranganathan; Deepak Cyril D'Souza Journal: Biol Psychiatry Date: 2015-03-30 Impact factor: 13.382
Authors: Qian Luo; Duo Xu; Tyler Roskos; Jeff Stout; Lynda Kull; Xi Cheng; Diane Whitson; Erich Boomgarden; Jeffrey Gfeller; Richard D Bucholz Journal: J Neurotrauma Date: 2013-08-31 Impact factor: 5.269
Authors: Matthew J Brookes; Emma L Hall; Siân E Robson; Darren Price; Lena Palaniyappan; Elizabeth B Liddle; Peter F Liddle; Stephen E Robinson; Peter G Morris Journal: PLoS One Date: 2015-04-17 Impact factor: 3.240