Literature DB >> 21592793

Synthesis and application of an N-acylated l-homoserine lactone derivatized affinity matrix for the isolation of quorum sensing signal receptors.

Thanit Praneenararat1, Teresa M J Beary, Anthony S Breitbach, Helen E Blackwell.   

Abstract

The design and synthesis of an agarose resin functionalized with a Gram-negative quorum sensing (QS) signaling molecule analogue is described. The modified resin was utilized in affinity pull-down assays to successfully isolate QscR, a LuxR-type QS receptor from Pseudomonas aeruginosa. This resin may facilitate the identification of novel QS signal receptors using affinity chromatography techniques.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21592793      PMCID： PMC3513337          DOI： 10.1016/j.bmcl.2011.04.062

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  41 in total

1.  Acyl-homoserine lactone binding to and stability of the orphan Pseudomonas aeruginosa quorum-sensing signal receptor QscR.

Authors:  Ken-Ichi Oinuma; E Peter Greenberg
Journal:  J Bacteriol       Date:  2010-11-19       Impact factor: 3.490

Review 2.  The roles of extracellular proteins, polysaccharides and signals in the interactions of rhizobia with legume roots.

Authors:  J Allan Downie
Journal:  FEMS Microbiol Rev       Date:  2009-12-15       Impact factor: 16.408

3.  Mastering the chemical language of bacteria.

Authors:  Warren R J D Galloway; James T Hodgkinson; Martin Welch; David R Spring
Journal:  Chem Biol       Date:  2009-09-25

4.  Synthesis and validation of a probe to identify quorum sensing receptors.

Authors:  Luba Dubinsky; Lucja M Jarosz; Neri Amara; Pnina Krief; Vladimir V Kravchenko; Bastiaan P Krom; Michael M Meijler
Journal:  Chem Commun (Camb)       Date:  2009-10-28       Impact factor: 6.222

5.  Small molecules that modulate quorum sensing and control virulence in Pseudomonas aeruginosa.

Authors:  Margrith E Mattmann; Helen E Blackwell
Journal:  J Org Chem       Date:  2010-10-15       Impact factor: 4.354

6.  What's in a name? The semantics of quorum sensing.

Authors:  Thomas G Platt; Clay Fuqua
Journal:  Trends Microbiol       Date:  2010-06-21       Impact factor: 17.079

7.  Discovery of a quorum sensing modulator pharmacophore by 3D small-molecule microarray screening.

Authors:  David M Marsden; Rebecca L Nicholson; Mette E Skindersoe; Warren R J D Galloway; Hannah F Sore; Michael Givskov; George P C Salmond; Mark Ladlow; Martin Welch; David R Spring
Journal:  Org Biomol Chem       Date:  2010-09-30       Impact factor: 3.876

8.  In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect.

Authors:  Thomas Bjarnsholt; Maria van Gennip; Tim H Jakobsen; Louise D Christensen; Peter Ø Jensen; Michael Givskov
Journal:  Nat Protoc       Date:  2010-01-28       Impact factor: 13.491

9.  Medicinal chemistry as a conduit for the modulation of quorum sensing.

Authors:  Colin A Lowery; Nicholas T Salzameda; Daisuke Sawada; Gunnar F Kaufmann; Kim D Janda
Journal:  J Med Chem       Date:  2010-11-11       Impact factor: 7.446

10.  Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor.

Authors:  Yaozhong Zou; Satish K Nair
Journal:  Chem Biol       Date:  2009-09-25
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  5 in total

1.  Species selective diazirine positioning in tag-free photoactive quorum sensing probes.

Authors:  Luba Dubinsky; Antonia Delago; Neri Amara; Pnina Krief; Josep Rayo; Tsaffrir Zor; Vladimir V Kravchenko; Michael M Meijler
Journal:  Chem Commun (Camb)       Date:  2013-05-24       Impact factor: 6.222

2.  Chemical methods to interrogate bacterial quorum sensing pathways.

Authors:  Thanit Praneenararat; Andrew G Palmer; Helen E Blackwell
Journal:  Org Biomol Chem       Date:  2012-10-03       Impact factor: 3.876

3.  Design and synthesis of a biotinylated chemical probe for detecting the molecular targets of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin.

Authors:  Ysobel R Baker; Warren R J D Galloway; James T Hodgkinson; David R Spring
Journal:  Molecules       Date:  2013-09-25       Impact factor: 4.411

4.  The Pseudomonas aeruginosa N-acylhomoserine lactone quorum sensing molecules target IQGAP1 and modulate epithelial cell migration.

Authors:  Thommie Karlsson; Maria V Turkina; Olena Yakymenko; Karl-Eric Magnusson; Elena Vikström
Journal:  PLoS Pathog       Date:  2012-10-11       Impact factor: 6.823

Review 5.  Quorum sensing communication between bacteria and human cells: signals, targets, and functions.

Authors:  Angelika Holm; Elena Vikström
Journal:  Front Plant Sci       Date:  2014-06-26       Impact factor: 5.753
  5 in total

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