Literature DB >> 21591758

A new class of phenazines with activity against a chloroquine resistant Plasmodium falciparum strain and antimicrobial activity.

Hidayat Hussain1, Sabine Specht, Salem R Sarite, Michael Saeftel, Achim Hoerauf, Barbara Schulz, Karsten Krohn.   

Abstract

New phenazines were synthesized by oxygenation of 1- and 2-naphthol with transition metal peroxo complexes and in situ reaction with 1,2-diamines. The title compounds were evaluated for in vitro antimalarial activity against Plasmodium falciparum and chloroquine-resistant strains. Phenazines 12, 27, and 28 were most prominent in growth inhibition. In vivo protection against cerebral malaria was observed with the phenazines 11, 12, 20, and 27, whereas partial protection was provided by 19.

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Year:  2011        PMID： 21591758     DOI： 10.1021/jm200302d

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  8 in total

1.  One-pot multicomponent synthesis of benzophenazine tethered tetrahydropyridopyrimidine derivatives.

Authors:  Tasneem Parvin
Journal:  Mol Divers       Date:  2022-04-23       Impact factor: 2.943

2.  An efficient and environmentally sustainable domino protocol for the synthesis of structurally diverse spiroannulated pyrimidophenazines using erbium doped TiO2 nanoparticles as a recyclable and reusable heterogeneous acid catalyst.

Authors:  Kanchan Verma; Yogesh Kumar Tailor; Sarita Khandelwal; Monu Agarwal; Esha Rushell; Yogita Kumari; Kamlendra Awasthi; Mahendra Kumar
Journal:  RSC Adv       Date:  2018-08-28       Impact factor: 4.036

Review 3.  Recent advances in malaria drug discovery.

Authors:  Marco A Biamonte; Jutta Wanner; Karine G Le Roch
Journal:  Bioorg Med Chem Lett       Date:  2013-03-27       Impact factor: 2.823

4.  Nucleoside-Lipid-Based Nanoparticles for Phenazine Delivery: A New Therapeutic Strategy to Disrupt Hsp27-eIF4E Interaction in Castration Resistant Prostate Cancer.

Authors:  Hajer Ziouziou; Clément Paris; Sébastien Benizri; Thi Khanh Le; Claudia Andrieu; Dang Tan Nguyen; Ananda Appavoo; David Taïeb; Frédéric Brunel; Ridha Oueslati; Olivier Siri; Michel Camplo; Philippe Barthélémy; Palma Rocchi
Journal:  Pharmaceutics       Date:  2021-04-27       Impact factor: 6.321

5.  Synthesis of pyrrolo[3,2-a]phenazines from 5-nitroindoles and anilines.

Authors:  Zbigniew Wróbel; Michał Więcław; Robert Bujok; Krzysztof Wojciechowski
Journal:  Monatsh Chem       Date:  2013-10-10       Impact factor: 1.451

6.  Room temperature stable multitalent: highly reactive and versatile copper guanidine complexes in oxygenation reactions.

Authors:  Melanie Paul; Alexander Hoffmann; Sonja Herres-Pawlis
Journal:  J Biol Inorg Chem       Date:  2021-02-17       Impact factor: 3.358

7.  ANTHELMINTIC ACTIVITY OF LAPACHOL, β-LAPACHONE AND ITS DERIVATIVES AGAINST Toxocara canis LARVAE.

Authors:  Taís Mata-Santos; Nitza França Pinto; Hilton Antônio Mata-Santos; Kelly Gallan De Moura; Paula Fernandes Carneiro; Tatiane Dos Santos Carvalho; Karina Pena Del Rio; Maria do Carmo Freire Ribeiro Pinto; Lourdes Rodrigues Martins; Juliana Montelli Fenalti; Pedro Eduardo Almeida Da Silva; Carlos James Scaini
Journal:  Rev Inst Med Trop Sao Paulo       Date:  2015 May-Jun       Impact factor: 2.169

8.  Axial chiral bisbenzophenazines: solid-state self-assembly via halide hydrogen bonds triggered by linear alkanes.

Authors:  Alison E Metz; Erin E Podlesny; Patrick J Carroll; Ariel N Klinghoffer; Marisa C Kozlowski
Journal:  J Am Chem Soc       Date:  2014-07-18       Impact factor: 15.419
  8 in total

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