Literature DB >> 215905

Apurinic and/or apyrimidinic endonuclease activity in ataxia telangiectasia cell extracts.

R B Sheridan, P C Huang.   

Abstract

The possibility that the increased sensitivity of ataxia telangiectasia towards ionizing radiation is related to a DNA-repair deficiency has been examined further. When compared to unaffected controls, 6 lines of fibroblast cells derived from ataxia patients demonstrated a slightly reduced endonucleolytic activity (165 +/- 12 units vs. 214 +/- 28 units) towards apurinic and/or apyrimidinic sites as determined in a "nicking" assay.

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Year:  1978        PMID： 215905     DOI： 10.1016/0027-5107(78)90101-x

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  4 in total

Review 1.  Genetic and biochemical studies with ataxia telangiectasia. A review.

Authors:  P C Huang; R B Sheridan
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

2.  The response of ataxia telangiectasia cells to bleomycin.

Authors:  A R Lehmann; S Stevens
Journal:  Nucleic Acids Res       Date:  1979       Impact factor: 16.971

3.  Isolation and characterization of monoclonal antibodies directed against the DNA repair enzyme uracil DNA glycosylase from human placenta.

Authors:  P Arenaz; M A Sirover
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

4.  An apparent correlation between the inhibition of induced ornithine decarboxylase activity by gamma radiation and the capacity for DNA repair synthesis in normal and ataxia telangiectasia human fibroblasts: no correlation with cell survival.

Authors:  E Ben-Hur; R Kol; Y M Heimer; Y Shiloh; E Tabor; Y Becker
Journal:  Radiat Environ Biophys       Date:  1981       Impact factor: 1.925
  4 in total

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