Literature DB >> 21590482

Inhibition of fibroblast growth factor receptor 1: influence on tympanic membrane wound healing in rats.

Holger Kaftan1, Lars Reuther, Bärbel Miehe, Werner Hosemann, Achim Beule.   

Abstract

An animal model of chronic tympanic membrane (TM) perforation is needed for experiments on supporting healing of TM perforations. The basic fibroblast growth factor is important in TM wound healing. The object of this study was to investigate the efficacy of fibroblast growth factor receptor 1 (FGFR1) inhibition to arrest wound healing of experimental TM perforation. Bilateral instrumental myringotomies were performed in 12 rats. A specific inhibitor of the FGFR1 tyrosine kinase (SU5402) was applied to the left TM (2 mg/ml) and to the right TM (10 mg/ml) of each animal daily for 12 consecutive days. Thereafter, TMs were observed weekly for a total of 30 days. TM healing was delayed in a dose-dependent manner. We observed differences in the histologic parameters between both groups. SU 5402 is a strong inhibitor of TM healing but seems not to be suitable to create a chronic TM perforation in rat.

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Year:  2011        PMID： 21590482     DOI： 10.1007/s00405-011-1627-6

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN： 0937-4477            Impact factor:   2.503


  26 in total

1.  Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.

Authors:  M Mohammadi; G McMahon; L Sun; C Tang; P Hirth; B K Yeh; S R Hubbard; J Schlessinger
Journal:  Science       Date:  1997-05-09       Impact factor: 47.728

2.  [An improved animal model for chronic perforation of the tympanic membrane].

Authors:  H Kaftan; W Hosemann; A Beule; D Junghans
Journal:  HNO       Date:  2004-08       Impact factor: 1.284

3.  [Fibrin gel for treatment of tympanic membrane perforations: an experimental animal model].

Authors:  H Kaftan; D Eyrich; E Schindler; A Göpferich; W Hosemann
Journal:  HNO       Date:  2006-12       Impact factor: 1.284

4.  Histological study of the healing of traumatic tympanic membrane perforation after basic fibroblast growth factor application.

Authors:  M Mondain; A Ryan
Journal:  Laryngoscope       Date:  1993-03       Impact factor: 3.325

5.  Basic fibroblast growth factor combined with atelocollagen for closing chronic tympanic membrane perforations in 87 patients.

Authors:  Nobuhiro Hakuba; Michitaka Iwanaga; Shinzo Tanaka; Yasuyuki Hiratsuka; Yohei Kumabe; Masaya Konishi; Yusuke Okanoue; Nao Hiwatashi; Tadahiko Wada
Journal:  Otol Neurotol       Date:  2010-01       Impact factor: 2.311

6.  The accelerating effect of histamine on the cutaneous wound-healing process through the action of basic fibroblast growth factor.

Authors:  Yukikazu Numata; Tadashi Terui; Ryuhei Okuyama; Noriyasu Hirasawa; Yoshie Sugiura; Ichiro Miyoshi; Takehiko Watanabe; Atsuo Kuramasu; Hachiro Tagami; Hiroshi Ohtsu
Journal:  J Invest Dermatol       Date:  2006-06       Impact factor: 8.551

7.  Direct application of basic fibroblast growth factor improves tympanic membrane perforation healing.

Authors:  M Fina; A Baird; A Ryan
Journal:  Laryngoscope       Date:  1993-07       Impact factor: 3.325

8.  Epidermal growth factor and basic fibroblast growth factor are induced in guinea-pig tympanic membrane following traumatic perforation.

Authors:  M Mondain; A Ryan
Journal:  Acta Otolaryngol       Date:  1995-01       Impact factor: 1.494

9.  The influence of inhibition of the epidermal growth factor receptor on tympanic membrane wound healing in rats.

Authors:  Holger Kaftan; Lars Reuther; Bärbel Miehe; Werner Hosemann; Michael Herzog
Journal:  Growth Factors       Date:  2010-08       Impact factor: 2.511

10.  Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition.

Authors:  Hendrik Fischer; Ninon Taylor; Sigrid Allerstorfer; Michael Grusch; Gudrun Sonvilla; Klaus Holzmann; Ulrike Setinek; Leonilla Elbling; Heidelinde Cantonati; Bettina Grasl-Kraupp; Christine Gauglhofer; Brigitte Marian; Michael Micksche; Walter Berger
Journal:  Mol Cancer Ther       Date:  2008-10       Impact factor: 6.261
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  8 in total

1.  Biocompatibility evaluation of cigarette and carbon papers used in repair of traumatic tympanic membrane perforations: experimental study.

Authors:  Emine Elif Altuntaş; Zeynep Sümer
Journal:  Eur Arch Otorhinolaryngol       Date:  2012-01-24       Impact factor: 2.503

2.  Functional Outcomes of Heparin-Binding Epidermal Growth Factor-Like Growth Factor for Regeneration of Chronic Tympanic Membrane Perforations in Mice.

Authors:  Peter Luke Santa Maria; Peter Gottlieb; Chloe Santa Maria; Sungwoo Kim; Sunil Puria; Yunzhi Peter Yang
Journal:  Tissue Eng Part A       Date:  2017-02-24       Impact factor: 3.845

3.  Heparin binding-epidermal growth factor-like growth factor for the regeneration of chronic tympanic membrane perforations in mice.

Authors:  Peter Luke Santa Maria; Sungwoo Kim; Yasin Kursad Varsak; Yunzhi Peter Yang
Journal:  Tissue Eng Part A       Date:  2015-03-17       Impact factor: 3.845

4.  Ozone improved the wound healing in type 2 diabetics via down-regulation of IL- 8, 10 and induction of FGFR expression.

Authors:  Olga Teplyakova; Yurii Vinnik; Anna Drobushevskaya; Natalia Malinovskaya; Andrey Kirichenko; Darya Ponedelnik
Journal:  Acta Biomed       Date:  2022-05-11

Review 5.  Effect of tyrosine kinase inhibitors on wound healing and tissue repair: implications for surgery in cancer patients.

Authors:  Devron R Shah; Shamik Dholakia; Rashmi R Shah
Journal:  Drug Saf       Date:  2014-03       Impact factor: 5.606

6.  A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane.

Authors:  Stacey M Frumm; Shengyang Kevin Yu; Joseph Chang; Jordan A Artichoker; Sonia M Scaria; Katharine P Lee; Lauren E Byrnes; Julie B Sneddon; Aaron D Tward
Journal:  Cell Stem Cell       Date:  2020-11-11       Impact factor: 25.269

7.  Animal models of chronic tympanic membrane perforation: in response to plasminogen initiates and potentiates the healing of acute and chronic tympanic membrane perforations in mice.

Authors:  Allen Y Wang; Yi Shen; Jeffrey T Wang; Robert H Eikelboom; Rodney J Dilley
Journal:  Clin Transl Med       Date:  2014-03-26

8.  Basic fibroblast growth factor reduces scar by inhibiting the differentiation of epidermal stem cells to myofibroblasts via the Notch1/Jagged1 pathway.

Authors:  Peng Wang; Bin Shu; Yingbin Xu; Jiayuan Zhu; Jian Liu; Ziheng Zhou; Lei Chen; Jingling Zhao; Xusheng Liu; Shaohai Qi; Kun Xiong; Julin Xie
Journal:  Stem Cell Res Ther       Date:  2017-05-16       Impact factor: 6.832
  8 in total

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