Literature DB >> 2159030

Demonstration of Epstein-Barr virus in primary brain lymphoma by in situ DNA hybridisation in paraffin wax embedded tissue.

J K Murphy1, L S Young, I S Bevan, F A Lewis, D Dockey, J W Ironside, C J O'Brien, M Wells.   

Abstract

Tumour tissue from 29 patients with primary brain lymphoma was reviewed to determine if there was an aetiological association between Epstein-Barr virus and polyclonal and monoclonal lymphoproliferations. The morphology and immunophenotype in 24 patients for whom paraffin wax embedded tissue was available were studied. A high grade pleomorphic tumour morphology with plasmacytoid features was seen in 13 tumours. Because of the large number of pleomorphic lymphomas, all tumours were examined for the presence of the Epstein-Barr virus genome using in situ DNA hybridisation. A panel of three biotinylated probes to different sequences in the Epstein-Barr virus genome was used. Positive hybridisation with one or more probes was shown in tumours from 11 patients. The remaining tumours gave no hybridisation signal. There was no correlation between positive hybridisation and morphological subtype or clinical outcome.

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Year:  1990        PMID： 2159030      PMCID： PMC502334          DOI： 10.1136/jcp.43.3.220

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  23 in total

1.  Immunodeficiency to the Epstein-Barr virus in the X-linked recessive lymphoproliferative syndrome.

Authors:  D T Purtilo; L Hutt; J Bhawan; J P Yang; C Cassel; S Allegra; F S Rosen
Journal:  Clin Immunol Immunopathol       Date:  1978-02

2.  Rapid evolution of central nervous system lymphoma in renal transplant recipient.

Authors:  S S Mirra; I J Check; J D Porter; G W Cox; M L Miles; K M Weidenheim
Journal:  Lancet       Date:  1981-10-17       Impact factor: 79.321

3.  Long-term T-cell-mediated immunity to Epstein-Barr virus.

Authors:  A B Rickinson; D J Moss; L E Wallace; M Rowe; I S Misko; M A Epstein; J H Pope
Journal:  Cancer Res       Date:  1981-11       Impact factor: 12.701

4.  Selective immunodeficiency and malignant lymphoma of the central nervous system. Possible relationship to the Epstein-Barr virus.

Authors:  P K Pattengale; C R Taylor; T Panke; D Tatter; R A McCormick; D G Rawlinson; R L Davis
Journal:  Acta Neuropathol       Date:  1979-12       Impact factor: 17.088

5.  Growth of diploid, Epstein-Barr virus-carrying human lymphoblastoid cell lines heterotransplanted into nude mice under immunologically privileged conditions.

Authors:  B Giovanella; K Nilsson; L Zech; O Yim; G Klein; J S Stehlin
Journal:  Int J Cancer       Date:  1979-07-15       Impact factor: 7.396

6.  Epstein-Barr-virus-carrying lymphoma in a patient with ataxia-telangiectasia.

Authors:  A K Saemundsen; A I Berkel; W Henle; G Henle; M Anvret; O Sanal; F Ersoy; M Cağlar; G Klein
Journal:  Br Med J (Clin Res Ed)       Date:  1981-02-07

7.  Clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of Epstein-Barr virus.

Authors:  D W Hanto; G Frizzera; D T Purtilo; K Sakamoto; J L Sullivan; A K Saemundsen; G Klein; R L Simmons; J S Najarian
Journal:  Cancer Res       Date:  1981-11       Impact factor: 12.701

8.  Morphologic and immunophenotypic characterization of primary brain lymphomas using paraffin-embedded tissue.

Authors:  J K Murphy; C J O'Brien; J W Ironside
Journal:  Histopathology       Date:  1989-11       Impact factor: 5.087

9.  Polymorphic diffuse B-cell hyperplasias and lymphomas in renal transplant recipients.

Authors:  G Frizzera; D W Hanto; K J Gajl-Peczalska; J Rosai; R W McKenna; R K Sibley; K P Holahan; L L Lindquist
Journal:  Cancer Res       Date:  1981-11       Impact factor: 12.701

Review 10.  Immune deficiency predisposing to Epstein-Barr virus-induced lymphoproliferative diseases: the X-linked lymphoproliferative syndrome as a model.

Authors:  D T Purtilo
Journal:  Adv Cancer Res       Date:  1981       Impact factor: 6.242
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  9 in total

1.  Epstein-Barr and human immunodeficiency viruses in acquired immunodeficiency syndrome-related primary central nervous system lymphoma.

Authors:  S Morgello
Journal:  Am J Pathol       Date:  1992-08       Impact factor: 4.307

2.  Detection of single copies of Epstein-Barr virus in paraffin wax sections by non-radioactive in situ hybridisation.

Authors:  P J Coates; W P Mak; G Slavin; A J d'Ardenne
Journal:  J Clin Pathol       Date:  1991-06       Impact factor: 3.411

3.  Epstein-Barr virus and brain lymphomas.

Authors:  R M Bashir; F H Hochberg; M X Wei
Journal:  J Neurooncol       Date:  1995       Impact factor: 4.130

Review 4.  Primary central nervous system lymphoma.

Authors:  W S Velasquez
Journal:  J Neurooncol       Date:  1994       Impact factor: 4.130

5.  Detection of Epstein-Barr virus genomes in AIDS related lymphomas: sensitivity and specificity of in situ hybridisation compared with Southern blotting.

Authors:  S J Hamilton-Dutoit; H J Delecluse; M Raphael; G Lenoir; G Pallesen
Journal:  J Clin Pathol       Date:  1991-08       Impact factor: 3.411

Review 6.  Primary central nervous system lymphomas--an update.

Authors:  K A Jellinger; W Paulus
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

7.  Primary cerebral lymphoma: a study of 47 cases probed for Epstein-Barr virus genome.

Authors:  J F Geddes; M B Bhattacharjee; K Savage; F Scaravilli; J E McLaughlin
Journal:  J Clin Pathol       Date:  1992-07       Impact factor: 3.411

8.  A survey of Epstein-Barr virus gene expression in sporadic non-Hodgkin's lymphomas. Detection of Epstein-Barr virus in a subset of peripheral T-cell lymphomas.

Authors:  S J Hamilton-Dutoit; G Pallesen
Journal:  Am J Pathol       Date:  1992-06       Impact factor: 4.307

Review 9.  Immune regulation in Epstein-Barr virus-associated diseases.

Authors:  R Khanna; S R Burrows; D J Moss
Journal:  Microbiol Rev       Date:  1995-09
  9 in total

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