Literature DB >> 215899

Partial purification and characterization of cyclic nucleotide phosphodiesterases from human bronchial tissue.

H Bergstrand, B Lundquist.   

Abstract

DEAE-Sephadex chromatography reveals the presence in extracts of human bronchial tissue of at least three separate cyclic nucleotide phosphodiesterases: a cyclic GMP-specific high affinity enzyme, a non-specific low affinity enzyme, and a high affinity cyclic AMP-specific enzyme. The activity of each fraction was partially characterized with respect to kinetic parameters, thermal stability, and the influence of a number of inhibitors. Each activity was found to resemble the activity of the previously characterized corresponding enzyme from whole lung tissue extracts. A high affinity non-specific phospho-diesterase previously isolated from lung tissue is missing in extracts of bronchial tissue.

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Year:  1978        PMID： 215899     DOI： 10.1007/bf00230191

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  16 in total

1.  Statistical estimations in enzyme kinetics.

Authors:  G N WILKINSON
Journal:  Biochem J       Date:  1961-08       Impact factor: 3.857

Review 2.  Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase.

Authors:  B Weiss
Journal:  Adv Cyclic Nucleotide Res       Date:  1975

3.  Ca-2+/Mg-2+-dependent cyclic nucleotide phosphodiesterase and its activator protein.

Authors:  S Kakiuchi; R Yamazaki; Y Teshima; K Uenishi; E Miyamoto
Journal:  Adv Cyclic Nucleotide Res       Date:  1975

4.  Calcium-dependent cyclic nucleotide phosphodiesterase from brain identification of phospholipids as calcium-independent activators.

Authors:  D J Wolff; C O Brostrom
Journal:  Arch Biochem Biophys       Date:  1976-04       Impact factor: 4.013

5.  Cyclic 3':5'-nucleotide phosphodiesterase. Stimulation of bovine brain cytoplasmic enzyme by lysophosphatidylcholine.

Authors:  A L Pichard; W Y Cheung
Journal:  J Biol Chem       Date:  1977-07-25       Impact factor: 5.157

Review 6.  Inhibitory and activators of cyclic nucleotide phosphodiesterase.

Authors:  M Chasin; D N Harris
Journal:  Adv Cyclic Nucleotide Res       Date:  1976

Review 7.  Cyclic nucleotide phosphodiesterases.

Authors:  M M Appleman; W J Thompson; T R Russell
Journal:  Adv Cyclic Nucleotide Res       Date:  1973

8.  The significance of abrupt transitions in Lineweaver-Burk plots with particular reference to glutamate dehydrogenase. Negative and positive co-operativity in catalytic rate constants.

Authors:  P C Engel; W Ferdinand
Journal:  Biochem J       Date:  1973-01       Impact factor: 3.857

9.  Separate phosphodiesterases for the hydrolysis of cyclic adenosine 3',5'-monophosphate and cyclic guanosine 3',5'-monophosphate in rat liver.

Authors:  T R Russell; W L Terasaki; M M Appleman
Journal:  J Biol Chem       Date:  1973-02-25       Impact factor: 5.157

10.  Partial purification and characterization of adenosine- and guanosine-3',5'-monophosphate phosphodiesterases from human lung tissue.

Authors:  H Bergstrand; B Lundquist
Journal:  Biochemistry       Date:  1976-04-20       Impact factor: 3.162
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  4 in total

Review 1.  Phosphodiesterase inhibitors: new opportunities for the treatment of asthma.

Authors:  T J Torphy; B J Undem
Journal:  Thorax       Date:  1991-07       Impact factor: 9.139

2.  Evidence that the peripheral cyclic AMP phosphodiesterase of rat liver plasma membranes is a metalloenzyme.

Authors:  J Londesborough
Journal:  Biochem J       Date:  1985-01-01       Impact factor: 3.857

3.  Human bronchial cyclic nucleotide phosphodiesterase isoenzymes: biochemical and pharmacological analysis using selective inhibitors.

Authors:  J de Boer; A J Philpott; R G van Amsterdam; M Shahid; J Zaagsma; C D Nicholson
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739

4.  Role of phosphodiesterase isoenzymes in regulating intracellular cyclic AMP in adenosine-stimulated smooth muscle cells.

Authors:  Y Xiong; E W Westhead; L L Slakey
Journal:  Biochem J       Date:  1995-01-15       Impact factor: 3.857
  4 in total

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