| Literature DB >> 2158953 |
A Luxen1, M Perlmutter, G T Bida, G Van Moffaert, J S Cook, N Satyamurthy, M E Phelps, J R Barrio.
Abstract
Regioselective radiofluorodemercuration of the 6-mercurio derivative 5 with [18F]acetylhypofluorite afforded, after acidic hydrolysis, 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (6-FD, 1) with a radiochemical yield of 11% (decay corrected and based on the total amount of [18F]F2 recovered from the target). 6-FD was obtained with a chemical and radiochemical purity of greater than 99% and with a level of mercury in the final preparation of less than 20 ppb. Utilization of a remote, semiautomated production system, resulted in the preparation of a sterile, pyrogen-free product suitable for human injection after a synthesis time of 50 min.Entities:
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Year: 1990 PMID： 2158953 DOI： 10.1016/0883-2889(90)90191-i
Source DB: PubMed Journal: Int J Rad Appl Instrum A ISSN： 0883-2889