Literature DB >> 2158905

Modulation of interleukin-1 beta production by cyclic AMP in human monocytes.

M Hurme1.   

Abstract

Elevation of cAMP has been considered to be an important downregulative signal in the production of interleukin-1(IL-1). This study demonstrates that this phenomenon is dependent on the signal used to activate the IL-1 production. The IL-1 beta production of lipopolysaccharide activated human monocytes was readily inhibited by dibutyryl cAMP. This took place without a significant change in the steady-state levels of IL-1 beta mRNA. By contrast, in PMA activated monocytes 100 microM dibutyryl cAMP increased in IL-1 beta production ca. 4-fold. The steady-state levels of IL-1 beta mRNA were also simultaneously increased.

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Year:  1990        PMID： 2158905     DOI： 10.1016/0014-5793(90)80699-j

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

1.  Endomorphin-2 modulates productions of TNF-alpha, IL-1beta, IL-10, and IL-12, and alters functions related to innate immune of macrophages.

Authors:  Yasutaka Azuma; Kiyoshi Ohura
Journal:  Inflammation       Date:  2002-10       Impact factor: 4.092

2.  The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium.

Authors:  S Devaraj; D Li; I Jialal
Journal:  J Clin Invest       Date:  1996-08-01       Impact factor: 14.808

3.  Induction of interleukin-1 production by ligands binding to the scavenger receptor in human monocytes and the THP-1 cell line.

Authors:  T Palkama
Journal:  Immunology       Date:  1991-11       Impact factor: 7.397

4.  Modulation of interleukin-1 and tumor necrosis factor expression by beta-adrenergic agonists in mouse ameboid microglial cells.

Authors:  E Hetier; J Ayala; A Bousseau; A Prochiantz
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

5.  The effects of antiinflammatory and antiallergic drugs on cytokine release after stimulation of human whole blood by lipopolysaccharide and zymosan A.

Authors:  D A Hartman; S J Ochalski; R P Carlson
Journal:  Inflamm Res       Date:  1995-07       Impact factor: 4.575

6.  Effects of prostaglandin E2, cholera toxin and 8-bromo-cyclic AMP on lipopolysaccharide-induced gene expression of cytokines in human macrophages.

Authors:  W W Zhong; P A Burke; M E Drotar; S R Chavali; R A Forse
Journal:  Immunology       Date:  1995-03       Impact factor: 7.397

7.  Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Comparison with IL-1 receptor antagonist.

Authors:  E Vannier; C A Dinarello
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

8.  The effects of anti-inflammatory and antiallergic drugs on the release of IL-1 beta and TNF-alpha in the human whole blood assay.

Authors:  D A Hartman; S J Ochalski; R P Carlson
Journal:  Agents Actions       Date:  1993

9.  Signal transduction pathways leading to the production of IL-8 by human monocytes are differentially regulated by dexamethasone.

Authors:  H S Anttila; S Reitamo; M Ceska; M Hurme
Journal:  Clin Exp Immunol       Date:  1992-09       Impact factor: 4.330

10.  Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1 beta gene.

Authors:  J Tsukada; K Saito; W R Waterman; A C Webb; P E Auron
Journal:  Mol Cell Biol       Date:  1994-11       Impact factor: 4.272
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