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Literature DB >> 2158840

Role of endothelium and calcium channels in endothelin-induced contraction of human cerebral arteries.

E M de Aguilera¹, A Irurzun, J M Vila, M Aldasoro, M S Galeote, S Lluch.

Abstract

Endothelin constricted human isolated cerebral arteries in a concentration-dependent manner. The maximal tension developed, as well as EC50 values were similar in arteries with and without endothelium. Removal of extracellular calcium or addition of the calcium antagonist nicardipine (10(-6)M), attenuated but did not abolish responses to endothelin. These experiments show that the endothelin-induced contraction in human cerebral arteries is not linked to the presence of intact endothelial cells. The data also show that the contractile effects of endothelin cannot be explained solely by an action on voltage-dependent calcium channels.

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Year: 1990 PMID： 2158840 PMCID： PMC1917334 DOI： 10.1111/j.1476-5381.1990.tb12945.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

6 in total

1. A novel potent vasoconstrictor peptide produced by vascular endothelial cells.

Authors: M Yanagisawa; H Kurihara; S Kimura; Y Tomobe; M Kobayashi; Y Mitsui; Y Yazaki; K Goto; T Masaki
Journal: Nature Date: 1988-03-31 Impact factor: 49.962

2. Endothelin and Ca++ agonist Bay K 8644: different vasoconstrictive properties.

Authors: M Auguet; S Delaflotte; P E Chabrier; E Pirotzky; F Clostre; P Braquet
Journal: Biochem Biophys Res Commun Date: 1988-10-14 Impact factor: 3.575

3. Increased endothelial cell turnover in areas of in vivo Evans Blue uptake in the pig aorta.

Authors: B A Caplan; C J Schwartz
Journal: Atherosclerosis Date: 1973 May-Jun Impact factor: 5.162

4. Endothelin-1 acts in cerebral arteries from the adventitial but not from the luminal side.

Authors: T Shigeno; T Mima; K Takakura; M Yanagisawa; A Saito; K Goto; T Masaki
Journal: J Cardiovasc Pharmacol Date: 1989 Impact factor: 3.105

5. Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.

Authors: W Martin; G M Villani; D Jothianandan; R F Furchgott
Journal: J Pharmacol Exp Ther Date: 1985-03 Impact factor: 4.030

6. Evidence for the direct effect of vasopressin on human and goat cerebral arteries.

Authors: S Lluch; M V Conde; G Diéguez; A L López de Pablo; M C González; C Estrada; B Gómez
Journal: J Pharmacol Exp Ther Date: 1984-03 Impact factor: 4.030

6 in total

5 in total

Role of endothelium and calcium channels in endothelin-induced contraction of human cerebral arteries.

1. A novel potent vasoconstrictor peptide produced by vascular endothelial cells.

2. Endothelin and Ca++ agonist Bay K 8644: different vasoconstrictive properties.

3. Increased endothelial cell turnover in areas of in vivo Evans Blue uptake in the pig aorta.

4. Endothelin-1 acts in cerebral arteries from the adventitial but not from the luminal side.

5. Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.

6. Evidence for the direct effect of vasopressin on human and goat cerebral arteries.

1. Effects of potassium channel opener KRN4884 on human conduit arteries used as coronary bypass grafts.

2. High sensitivity of porcine cerebral arteries to endothelin.

3. Comparison of the contractile effects of endothelin-1 and sarafotoxin S6b in goat isolated cerebral arteries.

4. Response of rabbit ear artery to endothelin-1 during cooling.

5. Interaction between endothelin and vasodilators in the human internal mammary artery.