Methyl 4-(cyclopropylmethoxy)-3-hydroxybenzoate [corrected].

In the title compound, C(12)H(14)O(4), the dihedral angle between the benzene ring and the cyclo-propyl ring is 60.3 (4)°. In the crystal structure, mol-ecules are linked by inter-molecular O-H⋯O hydrogen bonds into chains running parallel to [101].

Related literature

For bond-length and angle data for related structures, see: Bradley et al. (1992 ▶); Fifer & White (2005 ▶). During the development of PDE4 (phospho­diesterase-4) inhibitors, roflumilast was synthesized as the positive control in the bioactivity screening and the title compound was prepared as an inter­mediate. For the synthesis of roflumilast, see: Bose et al. (2005 ▶).

Experimental

Crystal data

C12H14O4

M = 222.23

Monoclinic,

a = 9.2326 (18) Å

b = 7.4747 (15) Å

c = 16.105 (3) Å

β = 102.22 (3)°

V = 1086.3 (4) Å3

Z = 4

Mo Kα radiation

μ = 0.10 mm−1

T = 113 K

0.24 × 0.22 × 0.12 mm

Data collection

Rigaku Saturn CCD area-detector diffractometer

Absorption correction: multi-scan (CrystalClear; Rigaku, 2005 ▶) T min = 0.976, T max = 0.988

7033 measured reflections

1904 independent reflections

1614 reflections with I > 2σ(I)

R int = 0.031

Refinement

R[F 2 > 2σ(F 2)] = 0.036

wR(F 2) = 0.100

S = 1.06

1904 reflections

148 parameters

H-atom parameters constrained

Δρmax = 0.27 e Å−3

Δρmin = −0.18 e Å−3

Data collection: CrystalClear (Rigaku, 2005 ▶); cell refinement: CrystalClear; data reduction: CrystalClear; program(s) used to solve structure: SHELXTL (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXTL; molecular graphics: SHELXTL; software used to prepare material for publication: SHELXTL.

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536810026826/rz2473sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536810026826/rz2473Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C12H14O4	F(000) = 472
Mr = 222.23	Dx = 1.359 Mg m−3
Monoclinic, P21/n	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2yn	Cell parameters from 3285 reflections
a = 9.2326 (18) Å	θ = 2.4–27.9°
b = 7.4747 (15) Å	µ = 0.10 mm−1
c = 16.105 (3) Å	T = 113 K
β = 102.22 (3)°	Block, colourless
V = 1086.3 (4) Å3	0.24 × 0.22 × 0.12 mm
Z = 4

Rigaku Saturn CCD area-detector diffractometer	1904 independent reflections
Radiation source: rotating anode	1614 reflections with I > 2σ(I)
confocal	Rint = 0.031
Detector resolution: 7.31 pixels mm-1	θmax = 25.0°, θmin = 2.4°
ω and φ scans	h = −10→10
Absorption correction: multi-scan (CrystalClear; Rigaku, 2005)	k = −8→8
Tmin = 0.976, Tmax = 0.988	l = −14→19
7033 measured reflections

Refinement on F2	Secondary atom site location: difference Fourier map
Least-squares matrix: full	Hydrogen site location: inferred from neighbouring sites
R[F2 > 2σ(F2)] = 0.036	H-atom parameters constrained
wR(F2) = 0.100	w = 1/[σ2(Fo2) + (0.070P)2] where P = (Fo2 + 2Fc2)/3
S = 1.06	(Δ/σ)max = 0.001
1904 reflections	Δρmax = 0.27 e Å−3
148 parameters	Δρmin = −0.18 e Å−3
0 restraints	Extinction correction: SHELXTL (Sheldrick, 2008), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4
Primary atom site location: structure-invariant direct methods	Extinction coefficient: 0.137 (12)

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
O1	1.20469 (11)	0.31399 (12)	0.41048 (5)	0.0325 (3)
O2	1.30178 (9)	0.17490 (11)	0.31110 (5)	0.0271 (3)
O3	0.89725 (9)	0.09184 (11)	0.06138 (5)	0.0239 (3)
H3	0.8217	0.1289	0.0271	0.036*
O4	0.65026 (9)	0.22515 (10)	0.10058 (5)	0.0201 (3)
C1	1.44532 (14)	0.17415 (17)	0.36957 (8)	0.0298 (3)
H1A	1.4785	0.2976	0.3822	0.045*
H1B	1.5174	0.1108	0.3436	0.045*
H1C	1.4368	0.1136	0.4223	0.045*
C2	1.19019 (14)	0.24965 (14)	0.33996 (8)	0.0216 (3)
C3	1.04746 (14)	0.24370 (13)	0.27724 (7)	0.0192 (3)
C4	1.03704 (13)	0.16800 (14)	0.19666 (7)	0.0186 (3)
H4	1.1222	0.1169	0.1817	0.022*
C5	0.90327 (13)	0.16755 (13)	0.13899 (7)	0.0170 (3)
C6	0.77661 (13)	0.23945 (13)	0.16152 (7)	0.0175 (3)
C7	0.78714 (14)	0.31575 (15)	0.24153 (7)	0.0211 (3)
H7	0.7020	0.3661	0.2568	0.025*
C8	0.92302 (14)	0.31775 (15)	0.29883 (8)	0.0217 (3)
H8	0.9305	0.3704	0.3533	0.026*
C9	0.51186 (13)	0.27000 (15)	0.12305 (7)	0.0215 (3)
H9A	0.5102	0.3987	0.1374	0.026*
H9B	0.4996	0.1998	0.1732	0.026*
C10	0.38989 (13)	0.22846 (15)	0.04938 (7)	0.0213 (3)
H10	0.3932	0.1075	0.0233	0.026*
C11	0.32129 (13)	0.37525 (17)	−0.00999 (8)	0.0274 (3)
H11A	0.3624	0.4974	0.0009	0.033*
H11B	0.2860	0.3447	−0.0707	0.033*
C12	0.23882 (13)	0.29816 (16)	0.05244 (8)	0.0241 (3)
H12A	0.1526	0.2203	0.0301	0.029*
H12B	0.2291	0.3730	0.1017	0.029*

	U11	U22	U33	U12	U13	U23
O1	0.0332 (6)	0.0402 (5)	0.0194 (5)	−0.0017 (4)	−0.0049 (4)	−0.0076 (4)
O2	0.0191 (5)	0.0353 (5)	0.0232 (5)	−0.0006 (3)	−0.0039 (4)	−0.0021 (4)
O3	0.0193 (5)	0.0356 (5)	0.0146 (4)	0.0066 (3)	−0.0014 (3)	−0.0044 (4)
O4	0.0138 (5)	0.0270 (5)	0.0183 (4)	0.0017 (3)	0.0006 (3)	−0.0009 (3)
C1	0.0184 (7)	0.0340 (7)	0.0312 (7)	−0.0028 (5)	−0.0080 (6)	0.0015 (6)
C2	0.0234 (7)	0.0186 (6)	0.0203 (6)	−0.0035 (4)	−0.0006 (5)	0.0027 (5)
C3	0.0224 (7)	0.0165 (6)	0.0166 (6)	−0.0030 (4)	−0.0003 (5)	0.0020 (4)
C4	0.0177 (6)	0.0190 (6)	0.0189 (6)	0.0004 (4)	0.0034 (5)	0.0012 (5)
C5	0.0205 (6)	0.0164 (6)	0.0132 (6)	−0.0008 (4)	0.0016 (5)	0.0002 (4)
C6	0.0178 (6)	0.0163 (6)	0.0172 (6)	−0.0011 (4)	0.0008 (5)	0.0031 (4)
C7	0.0208 (7)	0.0206 (6)	0.0223 (6)	0.0002 (5)	0.0058 (5)	−0.0016 (5)
C8	0.0272 (7)	0.0204 (6)	0.0168 (6)	−0.0031 (5)	0.0029 (5)	−0.0024 (5)
C9	0.0172 (7)	0.0242 (6)	0.0235 (6)	0.0031 (4)	0.0054 (5)	0.0004 (5)
C10	0.0163 (7)	0.0237 (6)	0.0233 (6)	0.0012 (4)	0.0031 (5)	−0.0016 (5)
C11	0.0205 (7)	0.0353 (7)	0.0259 (7)	0.0040 (5)	0.0041 (5)	0.0060 (5)
C12	0.0165 (7)	0.0284 (6)	0.0271 (7)	0.0005 (5)	0.0041 (5)	0.0007 (5)

O1—C2	1.2144 (14)	C6—C7	1.3936 (17)
O2—C2	1.3389 (15)	C7—C8	1.3913 (18)
O2—C1	1.4541 (14)	C7—H7	0.9500
O3—C5	1.3625 (13)	C8—H8	0.9500
O3—H3	0.8400	C9—C10	1.4855 (16)
O4—C6	1.3604 (14)	C9—H9A	0.9900
O4—C9	1.4394 (15)	C9—H9B	0.9900
C1—H1A	0.9800	C10—C12	1.4993 (17)
C1—H1B	0.9800	C10—C11	1.5043 (16)
C1—H1C	0.9800	C10—H10	1.0000
C2—C3	1.4816 (16)	C11—C12	1.4988 (17)
C3—C8	1.3845 (18)	C11—H11A	0.9900
C3—C4	1.4002 (16)	C11—H11B	0.9900
C4—C5	1.3792 (16)	C12—H12A	0.9900
C4—H4	0.9500	C12—H12B	0.9900
C5—C6	1.4028 (17)
C2—O2—C1	116.08 (9)	C3—C8—C7	120.58 (11)
C5—O3—H3	109.5	C3—C8—H8	119.7
C6—O4—C9	118.13 (9)	C7—C8—H8	119.7
O2—C1—H1A	109.5	O4—C9—C10	108.28 (9)
O2—C1—H1B	109.5	O4—C9—H9A	110.0
H1A—C1—H1B	109.5	C10—C9—H9A	110.0
O2—C1—H1C	109.5	O4—C9—H9B	110.0
H1A—C1—H1C	109.5	C10—C9—H9B	110.0
H1B—C1—H1C	109.5	H9A—C9—H9B	108.4
O1—C2—O2	123.32 (11)	C9—C10—C12	117.02 (10)
O1—C2—C3	123.75 (12)	C9—C10—C11	120.08 (10)
O2—C2—C3	112.92 (10)	C12—C10—C11	59.87 (8)
C8—C3—C4	119.77 (11)	C9—C10—H10	116.0
C8—C3—C2	118.84 (10)	C12—C10—H10	116.0
C4—C3—C2	121.38 (12)	C11—C10—H10	116.0
C5—C4—C3	120.08 (12)	C12—C11—C10	59.90 (8)
C5—C4—H4	120.0	C12—C11—H11A	117.8
C3—C4—H4	120.0	C10—C11—H11A	117.8
O3—C5—C4	118.40 (11)	C12—C11—H11B	117.8
O3—C5—C6	121.48 (10)	C10—C11—H11B	117.8
C4—C5—C6	120.10 (10)	H11A—C11—H11B	114.9
O4—C6—C7	125.49 (11)	C11—C12—C10	60.23 (8)
O4—C6—C5	114.69 (10)	C11—C12—H12A	117.7
C7—C6—C5	119.81 (11)	C10—C12—H12A	117.7
C8—C7—C6	119.63 (12)	C11—C12—H12B	117.7
C8—C7—H7	120.2	C10—C12—H12B	117.7
C6—C7—H7	120.2	H12A—C12—H12B	114.9
C1—O2—C2—O1	−0.02 (15)	C4—C5—C6—O4	−177.57 (9)
C1—O2—C2—C3	−179.41 (9)	O3—C5—C6—C7	179.98 (10)
O1—C2—C3—C8	1.07 (16)	C4—C5—C6—C7	1.75 (15)
O2—C2—C3—C8	−179.54 (9)	O4—C6—C7—C8	178.38 (9)
O1—C2—C3—C4	179.92 (10)	C5—C6—C7—C8	−0.86 (16)
O2—C2—C3—C4	−0.69 (14)	C4—C3—C8—C7	0.76 (16)
C8—C3—C4—C5	0.13 (16)	C2—C3—C8—C7	179.63 (10)
C2—C3—C4—C5	−178.71 (9)	C6—C7—C8—C3	−0.39 (16)
C3—C4—C5—O3	−179.66 (9)	C6—O4—C9—C10	−174.90 (9)
C3—C4—C5—C6	−1.38 (15)	O4—C9—C10—C12	−168.23 (9)
C9—O4—C6—C7	−8.73 (15)	O4—C9—C10—C11	−99.07 (12)
C9—O4—C6—C5	170.55 (9)	C9—C10—C11—C12	−105.72 (12)
O3—C5—C6—O4	0.66 (14)	C9—C10—C12—C11	110.76 (12)

D—H···A	D—H	H···A	D···A	D—H···A
O3—H3···O1i	0.84	2.00	2.7808 (14)	153

Table 1

Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
O3—H3⋯O1i	0.84	2.00	2.7808 (14)	153

Symmetry code: (i) .