2-O-tert-Butyl-dimethyl-silyl-4,6-O-ethyl-idene-myo-insitol 1,3,5-orthoformate.

In the title compound, C(15)H(26)O(6)Si, the dioxa six-membered ring bonded to the myo-inositol skeleton is in a boat conformation while the rest of the six-membered rings adopt chair conformations.

Related literature

myo-Inositol orthoesters have been used extensively for the synthesis of phospho­inositols and their derivatives, see: Das & Shashidhar (1997 ▶); Sureshan et al. (2003 ▶); Potter & Lampe (1995 ▶). For the synthesis of the title compound, see: Li & Vasella (1993 ▶). For a related structure, see: Angyal (2000 ▶).

Experimental

Crystal data

C15H26O6Si

M = 330.45

Orthorhombic,

a = 12.0170 (4) Å

b = 11.2808 (3) Å

c = 25.6942 (8) Å

V = 3483.14 (18) Å3

Z = 8

Mo Kα radiation

μ = 0.16 mm−1

T = 297 K

0.22 × 0.21 × 0.17 mm

Data collection

Bruker APEXII CCD area-detector diffractometer

Absorption correction: multi-scan (SADABS; Sheldrick, 2003 ▶) T min = 0.966, T max = 0.973

55999 measured reflections

4060 independent reflections

2035 reflections with I > 2σ(I)

R int = 0.102

Refinement

R[F 2 > 2σ(F 2)] = 0.052

wR(F 2) = 0.149

S = 1.00

4060 reflections

205 parameters

18 restraints

H-atom parameters constrained

Δρmax = 0.24 e Å−3

Δρmin = −0.23 e Å−3

Data collection: APEX2 (Bruker, 2007 ▶); cell refinement: SAINT (Bruker, 2007 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: SHELXTL (Sheldrick, 2008 ▶); software used to prepare material for publication: SHELXTL.

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536810023214/pv2294sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536810023214/pv2294Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C15H26O6Si	F(000) = 1424
Mr = 330.45	Dx = 1.260 Mg m−3
Orthorhombic, Pbca	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ac 2ab	Cell parameters from 3612 reflections
a = 12.0170 (4) Å	θ = 2.3–18.5°
b = 11.2808 (3) Å	µ = 0.16 mm−1
c = 25.6942 (8) Å	T = 297 K
V = 3483.14 (18) Å3	Block, colorless
Z = 8	0.22 × 0.21 × 0.17 mm

Bruker APEXII CCD area-detector diffractometer	4060 independent reflections
Radiation source: fine-focus sealed tube	2035 reflections with I > 2σ(I)
graphite	Rint = 0.102
φ and ω scans	θmax = 27.6°, θmin = 1.6°
Absorption correction: multi-scan (SADABS; Sheldrick, 2003)	h = −15→15
Tmin = 0.966, Tmax = 0.973	k = −14→14
55999 measured reflections	l = −33→32

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.052	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.149	H-atom parameters constrained
S = 1.00	w = 1/[σ2(Fo2) + (0.0588P)2 + 1.0231P] where P = (Fo2 + 2Fc2)/3
4060 reflections	(Δ/σ)max = 0.001
205 parameters	Δρmax = 0.24 e Å−3
18 restraints	Δρmin = −0.23 e Å−3

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
C1	1.0701 (3)	0.6537 (3)	0.59939 (13)	0.0839 (10)
H1A	1.1352	0.6900	0.5848	0.126*
H1B	1.0112	0.7110	0.6013	0.126*
H1C	1.0473	0.5886	0.5778	0.126*
C2	1.0960 (2)	0.6094 (2)	0.65278 (12)	0.0623 (8)
H2	1.1226	0.6746	0.6747	0.075*
C3	1.2002 (2)	0.4541 (3)	0.69423 (11)	0.0606 (8)
H3	1.2794	0.4578	0.7032	0.073*
C4	1.0113 (2)	0.4980 (2)	0.72188 (10)	0.0525 (6)
H4	0.9641	0.5327	0.7490	0.063*
C5	1.1318 (2)	0.4988 (3)	0.73907 (11)	0.0615 (7)
H5	1.1545	0.5797	0.7481	0.074*
C6	1.1663 (2)	0.3251 (2)	0.68424 (10)	0.0565 (7)
H6	1.2134	0.2913	0.6569	0.068*
C7	0.9784 (2)	0.3686 (2)	0.71229 (10)	0.0475 (6)
H7	0.8989	0.3641	0.7041	0.057*
C8	1.0450 (2)	0.3186 (2)	0.66778 (10)	0.0477 (6)
H8	1.0333	0.3668	0.6365	0.057*
C9	1.1140 (3)	0.3057 (3)	0.77096 (12)	0.0663 (8)
H9	1.1255	0.2570	0.8021	0.080*
C10	1.0905 (3)	0.2103 (4)	0.55151 (14)	0.1063 (13)
H10A	1.0859	0.2952	0.5534	0.160*
H10B	1.0710	0.1847	0.5171	0.160*
H10C	1.1651	0.1856	0.5593	0.160*
C11	1.0206 (3)	−0.0159 (3)	0.60583 (12)	0.0748 (9)
H11A	1.0988	−0.0286	0.6111	0.112*
H11B	0.9973	−0.0561	0.5748	0.112*
H11C	0.9800	−0.0465	0.6351	0.112*
C12	0.8465 (3)	0.1719 (3)	0.57919 (11)	0.0673 (8)
C13	0.8201 (3)	0.1084 (3)	0.52793 (12)	0.0919 (11)
H13A	0.7429	0.1190	0.5196	0.138*
H13B	0.8359	0.0254	0.5315	0.138*
H13C	0.8651	0.1411	0.5006	0.138*
C14	0.7693 (3)	0.1210 (4)	0.62207 (15)	0.1046 (12)
H14A	0.7834	0.1612	0.6543	0.157*
H14B	0.7837	0.0378	0.6262	0.157*
H14C	0.6930	0.1324	0.6122	0.157*
C15	0.8231 (4)	0.3032 (3)	0.57262 (19)	0.141 (2)
H15A	0.7474	0.3141	0.5618	0.212*
H15B	0.8722	0.3354	0.5468	0.212*
H15C	0.8351	0.3431	0.6052	0.212*
O1	0.99714 (14)	0.56100 (14)	0.67385 (7)	0.0554 (5)
O2	1.18006 (14)	0.52151 (17)	0.64779 (7)	0.0621 (5)
O3	1.14699 (17)	0.42203 (18)	0.78300 (7)	0.0728 (6)
O4	1.00096 (16)	0.30181 (15)	0.75876 (7)	0.0584 (5)
O5	1.18069 (15)	0.25908 (18)	0.73137 (8)	0.0689 (6)
O6	1.01461 (16)	0.19916 (15)	0.65769 (7)	0.0610 (5)
Si1	0.99324 (6)	0.14381 (6)	0.59918 (3)	0.0530 (2)

	U11	U22	U33	U12	U13	U23
C1	0.081 (2)	0.074 (2)	0.096 (3)	0.0003 (17)	0.0099 (19)	0.032 (2)
C2	0.0583 (17)	0.0506 (16)	0.078 (2)	−0.0097 (14)	0.0084 (15)	0.0002 (15)
C3	0.0401 (15)	0.077 (2)	0.0650 (18)	−0.0088 (14)	−0.0059 (13)	0.0029 (16)
C4	0.0549 (16)	0.0477 (14)	0.0550 (17)	−0.0024 (12)	0.0088 (13)	−0.0084 (13)
C5	0.0650 (18)	0.0632 (18)	0.0563 (18)	−0.0168 (15)	−0.0026 (14)	−0.0060 (15)
C6	0.0492 (15)	0.0673 (18)	0.0531 (17)	0.0093 (14)	0.0019 (13)	−0.0007 (14)
C7	0.0458 (15)	0.0451 (14)	0.0515 (16)	−0.0045 (11)	−0.0005 (12)	−0.0021 (12)
C8	0.0507 (15)	0.0432 (14)	0.0491 (16)	−0.0002 (11)	−0.0029 (12)	−0.0048 (12)
C9	0.072 (2)	0.070 (2)	0.0565 (18)	−0.0023 (16)	−0.0084 (16)	0.0069 (16)
C10	0.121 (3)	0.112 (3)	0.086 (3)	−0.040 (2)	0.038 (2)	−0.020 (2)
C11	0.093 (2)	0.0545 (17)	0.077 (2)	0.0151 (16)	−0.0045 (17)	−0.0142 (15)
C12	0.0784 (19)	0.0668 (17)	0.0567 (17)	0.0118 (15)	−0.0106 (15)	−0.0052 (14)
C13	0.104 (2)	0.096 (2)	0.076 (2)	0.0068 (19)	−0.0219 (18)	−0.0122 (18)
C14	0.072 (2)	0.142 (3)	0.100 (2)	0.008 (2)	0.0024 (19)	−0.005 (2)
C15	0.178 (5)	0.084 (3)	0.162 (4)	0.060 (3)	−0.091 (4)	−0.026 (3)
O1	0.0522 (10)	0.0465 (10)	0.0677 (12)	−0.0015 (8)	0.0059 (9)	0.0021 (9)
O2	0.0495 (11)	0.0730 (12)	0.0639 (12)	−0.0066 (9)	0.0089 (9)	0.0042 (11)
O3	0.0812 (14)	0.0844 (15)	0.0527 (12)	−0.0182 (11)	−0.0141 (10)	−0.0024 (11)
O4	0.0626 (12)	0.0582 (11)	0.0544 (12)	−0.0061 (9)	0.0037 (9)	0.0049 (9)
O5	0.0637 (12)	0.0759 (13)	0.0671 (14)	0.0167 (10)	−0.0079 (10)	0.0074 (11)
O6	0.0870 (14)	0.0419 (10)	0.0543 (11)	−0.0050 (9)	−0.0042 (10)	−0.0059 (8)
Si1	0.0636 (5)	0.0452 (4)	0.0502 (5)	−0.0004 (4)	0.0056 (4)	−0.0067 (3)

C1—C2	1.493 (4)	C9—O5	1.397 (3)
C1—H1A	0.9600	C9—O3	1.406 (3)
C1—H1B	0.9600	C9—H9	0.9800
C1—H1C	0.9600	C10—Si1	1.852 (3)
C2—O1	1.415 (3)	C10—H10A	0.9600
C2—O2	1.421 (3)	C10—H10B	0.9600
C2—H2	0.9800	C10—H10C	0.9600
C3—O2	1.436 (3)	C11—Si1	1.840 (3)
C3—C5	1.502 (4)	C11—H11A	0.9600
C3—C6	1.533 (4)	C11—H11B	0.9600
C3—H3	0.9800	C11—H11C	0.9600
C4—O1	1.434 (3)	C12—C15	1.516 (4)
C4—C5	1.513 (4)	C12—C13	1.532 (4)
C4—C7	1.533 (3)	C12—C14	1.550 (5)
C4—H4	0.9800	C12—Si1	1.864 (3)
C5—O3	1.434 (3)	C13—H13A	0.9600
C5—H5	0.9800	C13—H13B	0.9600
C6—O5	1.432 (3)	C13—H13C	0.9600
C6—C8	1.520 (3)	C14—H14A	0.9600
C6—H6	0.9800	C14—H14B	0.9600
C7—O4	1.437 (3)	C14—H14C	0.9600
C7—C8	1.505 (3)	C15—H15A	0.9600
C7—H7	0.9800	C15—H15B	0.9600
C8—O6	1.420 (3)	C15—H15C	0.9600
C8—H8	0.9800	O6—Si1	1.6480 (18)
C9—O4	1.395 (3)
C2—C1—H1A	109.5	O4—C9—H9	107.7
C2—C1—H1B	109.5	O5—C9—H9	107.7
H1A—C1—H1B	109.5	O3—C9—H9	107.7
C2—C1—H1C	109.5	Si1—C10—H10A	109.5
H1A—C1—H1C	109.5	Si1—C10—H10B	109.5
H1B—C1—H1C	109.5	H10A—C10—H10B	109.5
O1—C2—O2	111.3 (2)	Si1—C10—H10C	109.5
O1—C2—C1	107.8 (2)	H10A—C10—H10C	109.5
O2—C2—C1	107.4 (2)	H10B—C10—H10C	109.5
O1—C2—H2	110.1	Si1—C11—H11A	109.5
O2—C2—H2	110.1	Si1—C11—H11B	109.5
C1—C2—H2	110.1	H11A—C11—H11B	109.5
O2—C3—C5	111.6 (2)	Si1—C11—H11C	109.5
O2—C3—C6	108.6 (2)	H11A—C11—H11C	109.5
C5—C3—C6	107.5 (2)	H11B—C11—H11C	109.5
O2—C3—H3	109.7	C15—C12—C13	108.8 (3)
C5—C3—H3	109.7	C15—C12—C14	109.3 (3)
C6—C3—H3	109.7	C13—C12—C14	108.3 (3)
O1—C4—C5	111.2 (2)	C15—C12—Si1	111.8 (3)
O1—C4—C7	107.6 (2)	C13—C12—Si1	110.7 (2)
C5—C4—C7	107.4 (2)	C14—C12—Si1	107.9 (2)
O1—C4—H4	110.2	C12—C13—H13A	109.5
C5—C4—H4	110.2	C12—C13—H13B	109.5
C7—C4—H4	110.2	H13A—C13—H13B	109.5
O3—C5—C3	109.3 (2)	C12—C13—H13C	109.5
O3—C5—C4	110.4 (2)	H13A—C13—H13C	109.5
C3—C5—C4	107.3 (2)	H13B—C13—H13C	109.5
O3—C5—H5	109.9	C12—C14—H14A	109.5
C3—C5—H5	109.9	C12—C14—H14B	109.5
C4—C5—H5	109.9	H14A—C14—H14B	109.5
O5—C6—C8	109.0 (2)	C12—C14—H14C	109.5
O5—C6—C3	108.7 (2)	H14A—C14—H14C	109.5
C8—C6—C3	110.3 (2)	H14B—C14—H14C	109.5
O5—C6—H6	109.6	C12—C15—H15A	109.5
C8—C6—H6	109.6	C12—C15—H15B	109.5
C3—C6—H6	109.6	H15A—C15—H15B	109.5
O4—C7—C8	109.6 (2)	C12—C15—H15C	109.5
O4—C7—C4	108.5 (2)	H15A—C15—H15C	109.5
C8—C7—C4	109.9 (2)	H15B—C15—H15C	109.5
O4—C7—H7	109.6	C2—O1—C4	114.9 (2)
C8—C7—H7	109.6	C2—O2—C3	114.5 (2)
C4—C7—H7	109.6	C9—O3—C5	110.8 (2)
O6—C8—C7	110.9 (2)	C9—O4—C7	110.8 (2)
O6—C8—C6	110.0 (2)	C9—O5—C6	110.5 (2)
C7—C8—C6	106.3 (2)	C8—O6—Si1	124.48 (16)
O6—C8—H8	109.8	O6—Si1—C11	104.99 (12)
C7—C8—H8	109.8	O6—Si1—C10	110.57 (14)
C6—C8—H8	109.8	C11—Si1—C10	110.20 (17)
O4—C9—O5	112.5 (2)	O6—Si1—C12	109.54 (12)
O4—C9—O3	110.7 (2)	C11—Si1—C12	111.17 (15)
O5—C9—O3	110.5 (2)	C10—Si1—C12	110.25 (17)
O2—C3—C5—O3	174.7 (2)	C1—C2—O2—C3	−169.0 (2)
C6—C3—C5—O3	55.7 (3)	C5—C3—O2—C2	−4.0 (3)
O2—C3—C5—C4	54.9 (3)	C6—C3—O2—C2	114.4 (2)
C6—C3—C5—C4	−64.1 (3)	O4—C9—O3—C5	−62.2 (3)
O1—C4—C5—O3	−172.03 (19)	O5—C9—O3—C5	63.1 (3)
C7—C4—C5—O3	−54.5 (3)	C3—C5—O3—C9	−59.7 (3)
O1—C4—C5—C3	−52.9 (3)	C4—C5—O3—C9	58.1 (3)
C7—C4—C5—C3	64.6 (3)	O5—C9—O4—C7	−59.7 (3)
O2—C3—C6—O5	−176.93 (19)	O3—C9—O4—C7	64.4 (3)
C5—C3—C6—O5	−56.1 (3)	C8—C7—O4—C9	59.0 (3)
O2—C3—C6—C8	−57.5 (3)	C4—C7—O4—C9	−61.0 (3)
C5—C3—C6—C8	63.4 (3)	O4—C9—O5—C6	60.5 (3)
O1—C4—C7—O4	175.20 (18)	O3—C9—O5—C6	−63.7 (3)
C5—C4—C7—O4	55.3 (3)	C8—C6—O5—C9	−59.9 (3)
O1—C4—C7—C8	55.4 (3)	C3—C6—O5—C9	60.3 (3)
C5—C4—C7—C8	−64.5 (3)	C7—C8—O6—Si1	135.56 (19)
O4—C7—C8—O6	61.8 (3)	C6—C8—O6—Si1	−107.1 (2)
C4—C7—C8—O6	−179.1 (2)	C8—O6—Si1—C11	154.8 (2)
O4—C7—C8—C6	−57.9 (3)	C8—O6—Si1—C10	35.9 (2)
C4—C7—C8—C6	61.2 (3)	C8—O6—Si1—C12	−85.8 (2)
O5—C6—C8—O6	−61.8 (3)	C15—C12—Si1—O6	65.4 (3)
C3—C6—C8—O6	179.0 (2)	C13—C12—Si1—O6	−173.1 (2)
O5—C6—C8—C7	58.4 (3)	C14—C12—Si1—O6	−54.8 (2)
C3—C6—C8—C7	−60.8 (3)	C15—C12—Si1—C11	−179.0 (3)
O2—C2—O1—C4	53.3 (3)	C13—C12—Si1—C11	−57.5 (3)
C1—C2—O1—C4	170.8 (2)	C14—C12—Si1—C11	60.8 (3)
C5—C4—O1—C2	0.2 (3)	C15—C12—Si1—C10	−56.5 (3)
C7—C4—O1—C2	−117.2 (2)	C13—C12—Si1—C10	65.0 (3)
O1—C2—O2—C3	−51.2 (3)	C14—C12—Si1—C10	−176.7 (2)