Shengli Ding1, Pauline K Lund. 1. Department of Cell and Molecular Physiology, Center for Gastrointestinal Biology and Disease University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7574, USA.
Abstract
PURPOSE OF REVIEW: To highlight recent evidence supporting a concept that intestinal inflammation is a mediator or contributor to development of obesity and insulin resistance. RECENT FINDINGS: Current views suggest that obesity-associated systemic and adipose tissue inflammation promote insulin resistance, which underlies many obesity-linked health risks. Diet-induced changes in gut microbiota also contribute to obesity. Recent findings support a concept that high-fat diet and bacteria interact to promote early inflammatory changes in the small intestine that contribute to development of or susceptibility to obesity and insulin resistance. This review summarizes the evidence supporting a role of intestinal inflammation in diet-induced obesity and insulin resistance and discusses mechanisms. SUMMARY: The role of diet-induced intestinal inflammation as an early biomarker and mediator of obesity, and insulin resistance warrants further study.
PURPOSE OF REVIEW: To highlight recent evidence supporting a concept that intestinal inflammation is a mediator or contributor to development of obesity and insulin resistance. RECENT FINDINGS: Current views suggest that obesity-associated systemic and adipose tissue inflammation promote insulin resistance, which underlies many obesity-linked health risks. Diet-induced changes in gut microbiota also contribute to obesity. Recent findings support a concept that high-fat diet and bacteria interact to promote early inflammatory changes in the small intestine that contribute to development of or susceptibility to obesity and insulin resistance. This review summarizes the evidence supporting a role of intestinal inflammation in diet-induced obesity and insulin resistance and discusses mechanisms. SUMMARY: The role of diet-induced intestinal inflammation as an early biomarker and mediator of obesity, and insulin resistance warrants further study.
Authors: Fredrik Bäckhed; Jill K Manchester; Clay F Semenkovich; Jeffrey I Gordon Journal: Proc Natl Acad Sci U S A Date: 2007-01-08 Impact factor: 11.205
Authors: Marie A Hildebrandt; Christian Hoffmann; Scott A Sherrill-Mix; Sue A Keilbaugh; Micah Hamady; Ying-Yu Chen; Rob Knight; Rexford S Ahima; Frederic Bushman; Gary D Wu Journal: Gastroenterology Date: 2009-08-23 Impact factor: 22.682
Authors: Matam Vijay-Kumar; Catherine J Sanders; Rebekah T Taylor; Amrita Kumar; Jesse D Aitken; Shanthi V Sitaraman; Andrew S Neish; Satoshi Uematsu; Shizuo Akira; Ifor R Williams; Andrew T Gewirtz Journal: J Clin Invest Date: 2007-12 Impact factor: 14.808
Authors: Jacques Amar; Rémy Burcelin; Jean Bernard Ruidavets; Patrice D Cani; Josette Fauvel; Marie Christine Alessi; Bernard Chamontin; Jean Ferriéres Journal: Am J Clin Nutr Date: 2008-05 Impact factor: 7.045
Authors: Shengli Ding; Michael M Chi; Brooks P Scull; Rachael Rigby; Nicole M J Schwerbrock; Scott Magness; Christian Jobin; Pauline K Lund Journal: PLoS One Date: 2010-08-16 Impact factor: 3.240
Authors: Amanda L Thompson; Khristopher M Nicholas; Elijah Watson; Enrique Terán; Margaret E Bentley Journal: Am J Hum Biol Date: 2019-10-23 Impact factor: 1.937
Authors: J Le Beyec; A-L Pelletier; K Arapis; M Hourseau; F Cluzeaud; V Descatoire; R Ducroc; T Aparicio; F Joly; A Couvelard; J-P Marmuse; M Le Gall; A Bado Journal: Int J Obes (Lond) Date: 2014-01-28 Impact factor: 5.095
Authors: Theodoros Kelesidis; Michelle A Kendall; Otto O Yang; Howard N Hodis; Judith S Currier Journal: J Infect Dis Date: 2012-10-12 Impact factor: 5.226